Phase 1a Monotherapy Dose Escalation and Exploration: HER2 mutant, HER2 amplified or HER2 positive solid tumor Phase 1a Dose Escalation Combination with T-DXd: HER2 mutant Non-small Cell Lung Cancer Phase 1a Dose Escalation Combination with T-DM1: HER2 positive Metastatic Breast Cancer Phase 1b Monotherapy Dose Expansion: HER2 mutant Non-small Cell Lung Cancer

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