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Systemic Sclerosis (SSc) is a rare and orphan disease (DPCM 12 gennaio 2017-GU SG
n°65-S.O. n°15 - 18/03/2017), characterized by immunological, vascular and fibrotic
abnormalities. The estimated incidence is 18 to 20 cases per million population year
and a prevalence of 100 to 300 cases per million population. In Europe the prevalence
rate is estimated around 200 per million while in the Italian population around 20000
persons suffer from this form of autoimmune disease.
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