Metformin Hydrochloride — Drug Intelligence | 35 EU Trials

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35 Registered trials

16 Recruiting

16 Completed trials

34 Sponsors

12 Countries

Phase III

Phase II

Phase III: 13 Phase II: 17 Phase III/IV: 1 Phase IV: 3 Other: 1

Oversight events:

1 serious breach across 1 trial

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Indications tested

Primary progressive multiple sclerosis 1 Triple negative breast cancer 1 Clonal cytopenia of undetermined significance 1 Multiple sclerosis 1 Pre-eclampsia 1 Thyroid cancer 1 Vascular calcification 1 Li-Fraumeni syndrome 1 Secondary progressive multiple sclerosis 1 Uveal melanoma 1 Infertility female 1 Nodal osteoarthritis 1

Sponsors using this IMP

Assistance Publique Hopitaux De Paris 2 Fondazione IRCCS Istituto Nazionale Dei Tumori 2 Medical University Of Bialystok 2 Aarhus Universitet 1 Amsterdam UMC 1 Amsterdam UMC Stichting 1 Antwerp University Hospital 1 Bethesda Diabetes Research Center B.V. 1 Bispebjerg Hospital 1 Celltrion Inc. 1 Centre Hospitalier Universitaire De Bordeaux 1 Consorcio Centro De Investigacion Biomedica En Red 1

All trials — page 2

35 total

A clinical trial to test a combination of lifestyle-based intervention with metformin in preventing dementia. Ended

2022-500438-27-01 Phase II 2 countries Imperial College London
Clinical trial to evaluate Metformin compared with placebo for reversal of accelerated aging in persons living with HIV 50 years or older Ended

2024-512287-54-00 1 country Fundacion Para La Investigacion Biomedica Del Hospital Universitario La Paz
Methotrexate and Metformin in rheumatoid arthritis patients. Ended

2024-511033-35-00 Phase II 1 country Centre Hospitalier Universitaire De Bordeaux
Targeting triple negative BREAst cancer metabolism with a combination of chemotherapy and a diet mimicking FASTing plus/minus metformin in t… Ended

2023-508920-37-00 Phase II 1 country Fondazione IRCCS Istituto Nazionale Dei Tumori
An Efficacy and Safety Study of JNJ-42756493 in Participants with Urothelial Cancer Ended

2023-510273-34-00 Phase II 2 countries Janssen Cilag International
Clinical study to evaluate the efficacy and safety of Pioglitazone co-administration in patients with type II diabetes with insufficient gly… Ended

2023-508924-36-00 Phase III 1 country Celltrion Inc.
Randomised, double-blind, placebo-controlled study to evaluate the effect of metformin, an AMPK activator, on cognitive measures of progress… Ended

2024-518875-73-00 Phase III 1 country IIS La Fe
Metformin Intervention in children and adolescents with obesity. A parallel, three arms, randomized, 6 months, multi-center study with metfo… Ended

2024-517787-29-00 Phase II 1 country Region Uppsala
Study to evaluate the effect of metformin in the prevention of hyperglycemia in HR[+]/HER2[–] PIK3CA-mutated advanced breast cancer patients… Ended

2024-511295-33-00 Phase II 1 country Medica Scientia Innovation Research S.L.
DANHEART Ended

2024-514212-27-00 Phase III 1 country Aarhus Universitetshospital
A randomized controlled trial of two adjunctive host-directed therapies in rifampin-resistant tuberculosis (DRTB-HDT). Ended

2025-520745-80-00 Phase II 1 country Quality Regulatory Clinical Ireland Limited; The Aurum Institute

Showing 25–35 of 35 trials

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