Onfekafusp Alfa — Drug Intelligence | 12 EU Trials

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12 Registered trials

4 Recruiting

5 Completed trials

1 Sponsors

7 Countries

Phase III

Phase II

Phase III: 3 Phase II: 8 Phase I/II: 1

Indications tested

Basal cell carcinoma 2 Soft tissue sarcoma 2 Glioma 2 Squamous cell carcinoma of skin 1 Malignant melanoma stage III 1 Superficial spreading melanoma stage III 1

Sponsors using this IMP

Philogen S.p.A. 12

All trials

12 total

A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or Recurrence Not authorised

2024-515609-25-00 Phase II 2 countries Philogen S.p.A.
A study to evaluate the safety and efficacy of the tumor-targeting human antibody-cytokine fusion protein L19TNF plus standard temozolomide … Pending

2024-516357-46-00 Phase I/II 2 countries Philogen S.p.A.
A phase 2 study of the efficacy of intratumorally administered L19IL2 or L19TNF or L19IL2/L19TNF, all in combination with systemic anti-PD1 … Pending

2024-519326-20-00 Phase II 2 countries Philogen S.p.A.
L19IL2 or L19TNF or L19IL2/TNF in patients with basal cell carcinoma (BCC) Recruiting

2025-523229-16-00 Phase II 4 countries Philogen S.p.A.
L19IL2/TNF in patients with basal cell carcinoma Recruiting

2025-523230-77-00 Phase II 4 countries Philogen S.p.A.
L19IL2/L19TNF in patients with cutaneous squamous cell carcinoma Recruiting

2025-523231-19-00 Phase II 4 countries Philogen S.p.A.
Study of the efficacy of intratumoral injections of L19IL2 + L19TNF followed by surgery to prevent or retard appearance of new metastases Recruiting

2023-507119-36-00 Phase III 4 countries Philogen S.p.A.
L19IL2/L19TNF in skin cancer patients Ended

2024-518531-10-00 Phase II 3 countries Philogen S.p.A.
Efficacy and Safety of L19TNF in Previously Treated Patients With Advanced Stage or Metastatic Soft-tissue Sarcoma Ended

2024-512704-20-00 Phase II 5 countries Philogen S.p.A.
L19TNF plus doxorubicin in patients with STS Ended

2024-512789-32-00 Phase III 5 countries Philogen S.p.A.
Neoadjuvant L19IL2/L19TNF- Pivotal study Ended

2024-515749-40-00 Phase III 4 countries Philogen S.p.A.
L19IL2/L19TNF in patients with non-melanoma skin cancer. Ended

2024-518530-92-00 Phase II 2 countries Philogen S.p.A.

Showing 1–12 of 12 trials

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