Phase I – First Administration to Humans

783 trials 323 recruiting

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A study to find a suitable dose of BI 765883 and to test whether it helps people with advanced pancreatic cancer when taken alone or togethe… Ended

2023-508998-85-00 Metastatic pancreatic ductal adenocarcinoma (mPDAC) 2025-01-28
The safety and antibody response of the nasal COV2 vaccine against the SARS-CoV-2 virus Ended

2023-509725-49-00 Booster immunisation against COVID-19 disease caused by 2025-01-27
M1774 (oral ATR inhibitor) in Combination with PLX038 (Topo1 inhibitor) with dose expansion cohorts in patients with advanced solid tumors Ended

2023-505431-12-00 Patients with pretreated, metastatic or locally advance 2025-01-20
A Phase 1 Study of BGB-B3227 Alone and in Combination With Tislelizumab in Patients With Advanced or Metastatic Solid Tumors Ended

2024-514216-27-00 Solid tumors 2025-01-17
A PHASE-1, FIRST-IN-HUMAN, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE STUDY TO ASSESS THE SAFETY, TOL… Ended

2023-507504-31-00 Lupus erythematosus 2025-01-14
A Randomised Double-Blinded, Placebo-Controlled, Single and Multiple Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, and… Ended

2023-504838-21-00 Healthy 2025-01-08
First-in-human study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of VTX-PID in healthy male volunteers Ended

2023-503892-83-00 Healthy volunteers with circulating Neutralising antibo 2024-12-27
A Phase 1 Trial Assessing Pharmacokinetics and Safety of CAM2056 (Semaglutide Subcutaneous Depot) Ended

2024-518040-21-00 Body weight management 2024-12-18
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AB-101 Following Oral Administration in Healthy and Chronic Hepatitis B Subj… Ended

2023-508312-39-00 Chronic hepatitis B virus Infection 2024-12-13
Evaluation of safety, side effects and how the inhaled drug CHF10073 is absorbed, modified and removed from the body when administered alone… Ended

2024-515442-17-00 Pulmonary fibrosis 2024-12-03
A study to learn how different amounts of the study medicine called PF-07941944 are tolerated in the body of healthy adults. Ended

2024-515421-28-00 RSV (Respiratory Syncytial Virus) 2024-11-28
A Phase 1, randomized, double blind, single center, placebo controlled, single escalating weight-adjusted dose, safety study of HI-6 dimethy… Ended

2023-509020-17-00 Treatment of patients poisoned with organophosphorus co 2024-11-25
First administration of a single and increasing doses of BDT272 to assess its safety and pharmacokinetic in healthy volunteers Ended

2024-515415-22-00 Moderate to severe pain 2024-11-25
Optical PD-L1 imaging using Quantitative Fluorescence Endoscopy in locally advanced esophageal cancer using durvalumab-680LT: a phase I mult… Ended

2024-517258-85-00 Esophageal cancer 2024-11-21
A first-in-human study to investigate safety and tolerability of SAR446959 in participants with osteoarthritis of the knee Ended

2024-514015-96-00 Osteoarthritis 2024-11-20
A phase 1, randomized, double-blind, placebo-controlled study investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics… Ended

2024-512106-26-02 Cognitive impairment 2024-11-19
A study on the safety of and immune response to different doses of an mRNA vaccine against RSV in healthy adults. Ended

2024-512846-41-00 Respiratory Syncytial Virus Infections 2024-11-12
Single-Ascending Doses of 2-Methoxyestradiol in Healthy Non-Pregnant Female Subjects. Ended

2024-516854-23-00 No medical condition. 2024-11-11
A research study of a new medicine NNC0363-1063 in healthy participants and participants with type 1 diabetes Ended

2024-511808-17-00 Type 1 diabetes mellitus 2024-10-31
A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE AND MULTIPLE ASCENDING DOSE PHASE 1 STUDY TO INVESTIGATE THE SAFETY, TOLERABILITY, PH… Ended

2024-514871-17-00 Obesity 2024-10-29
A clinical study of the V540A vaccine in healthy adults (V540A-001) Ended

2024-515785-14-00 Human Papilloma virus 2024-10-22
A clinical study of MK-3214 in healthy people (MK-3214-001) Ended

2024-516016-17-00 Hypercholesterolaemia 2024-10-22
A study to test how well different doses of BI 3810477 are tolerated by healthy men Ended

2024-513419-28-00 Healthy volunteer trial 2024-10-22
A Clinical Trial to Assess the Safety of SOR102 in Healthy Participants and Patients with Ulcerative Colitis Ended

2023-510324-77-00 Ulcerative colitis 2024-10-20