Comparison of the efficacy of standard treatment associated with phage therapy versus standard treatment plus placebo for diabetic foot ulcers infected by Staphylococcus aureus

2022-500541-24-00 Protocol PHRC-N/2015/AS-01 Phase I and Phase II (Integrated) - Other Authorised, recruiting

Start 2 Jul 2024 · Status Authorised, recruiting · 1 EU/EEA countries · 7 sites · Protocol PHRC-N/2015/AS-01

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - Other
Status Authorised, recruiting
Participants planned 60
Countries 1
Sites 7

Diabetic foot

Key facts

Sponsor
Centre Hospitalier Universitaire De Nimes
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Bacterial Infections and Mycoses [C01]
Trial duration
2 Jul 2024 → ongoing
Decision date (initial)
2023-09-20
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2022-500541-24-00
ClinicalTrials.gov
NCT02664740

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Diabetic foot

VersionLevelCodeTermSystem organ class
21.1 LLT 10012664 Diabetic foot ulcer 10040785
20.1 PT 10060803 Diabetic foot infection 100000004862

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Centre Hospitalier Universitaire De Nimes

Sponsor organisation
Centre Hospitalier Universitaire De Nimes
Address
4 Place Du Professeur Robert Debre
City
Nimes Cedex 9
Postcode
30029
Country
France

Scientific contact point

Organisation
Centre Hospitalier Universitaire De Nimes
Contact name
Christophe MASSEGUIN, Project Manager

Public contact point

Organisation
Centre Hospitalier Universitaire De Nimes
Contact name
Christophe MASSEGUIN, Project Manager

Locations

1 EU/EEA country · 7 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruiting 60 7
Rest of world 0

Investigational sites

France

7 sites · Authorised, recruiting
Centre Hospitalier Universitaire De Bordeaux
Service de Médecine tropicale et pathologies infectieuses, Place Amelie Raba Leon, 33000, Bordeaux
Centre Hospitalier De Tourcoing
Service Universitaire des Maladies Infectieuses et du Voyageur, 155 Rue Du President Coty, Bp 40619, Tourcoing Cedex
Centre Hospitalier Intercommunal de Villeneuve Saint Georges
Service de Médecine Interne, Maladies Infectieuses et Tropicales, 40, allée de la source, Villeneuve-Saint-Georges
Centre Hospitalier Universitaire De Nimes
Service des Maladies Infectieuses et tropicales, 4 Place Du Professeur Robert Debre, Bp 40026, Nimes Cedex 9
Centre Hospitalier Universitaire De Nimes
Service de Maladies Métaboliques et Endocriniennes, Place Du Professeur Robert Debre, 30900, Nimes
Hopital Europeen Marseille
Service de Médecine interne, 6 Rue Desiree Clary, 13003, Marseille
Centre Hospitalier Universitaire De Toulouse
service de Diabétologie -Maladies Métaboliques- Nutrition, 1 Avenue Du Professeur Jean Poulhes, Tsa 50032, Toulouse Cedex 9

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2024-07-02

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-06-02 France Acceptable
2023-09-18
2023-09-20
2 SUBSTANTIAL MODIFICATION SM-2 2025-02-18 France Acceptable
2025-04-01
2025-04-16
3 SUBSTANTIAL MODIFICATION SM-3 2025-09-03 France Acceptable
2025-09-15
2025-09-29