Phase 1b study investigating the association of NP137 with mFOLFIRINOX in locally advanced pancreatic ductal adenocarcinoma LAP NET 1

2022-500905-42-00 Protocol 38RC22.0211 LAP NET1 Human pharmacology (Phase I) - Other Ended

Start 24 Mar 2023 · End 16 Jun 2025 · Status Ended · 1 EU/EEA countries · 10 sites · Protocol 38RC22.0211 LAP NET1

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 52
Countries 1
Sites 10

pancreatic ductal adenocarcinoma

Key facts

Sponsor
University Hospital Grenoble
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Digestive System Diseases [C06]
Trial duration
24 Mar 2023 → 16 Jun 2025
Decision date (initial)
2022-11-15
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

pancreatic ductal adenocarcinoma

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

University Hospital Grenoble

2 Total trials 2 Ended
Academic / Non-commercial
Sponsor organisation
University Hospital Grenoble
Address
Boulevard De La Chantourne, Cs 10217 La Tronche, La Tronche Cs 10217 La Tronche La Tronche
City
Grenoble Cedex 9
Postcode
38043
Country
France

Scientific contact point

Organisation
University Hospital Grenoble
Contact name
Anna BOROWIK

Public contact point

Organisation
University Hospital Grenoble
Contact name
Anna BOROWIK

Locations

1 EU/EEA country · 10 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ended 52 10
Rest of world 0

Investigational sites

France

10 sites · Ended
Centre Hospitalier Universitaire De Bordeaux
hepatogastroenterologie, Avenue De Magellan, 33600, Pessac
Hopital Prive Jean Mermoz
hepatogastroenterologie, 55 Avenue Jean Mermoz, 69008, Lyon
Assistance Publique Hopitaux De Paris
hepatogastroenterologie, 125 Rue De Stalingrad, 93000, Bobigny
Centre Hospitalier Universitaire De Poitiers
hepatogastroenterologie, 2 Rue De La Miletrie, 86000, Poitiers
Centre Hospitalier Universitaire De Rennes
hepatogastroenterologie, 2 Rue Henri Le Guilloux, 35033, Rennes Cedex 9
Centre Hospitalier Universitaire De Reims
hepatogastroenterologie, Rue Du General Koenig, 51092, Reims Cedex
Centre Leon Berard
Medical oncology, 28 Rue Laennec, 69008, Lyon
CHU Lille
oncology, Rue Michel Polonovski, 59037, Lille Cedex
Centre Hospitalier Universitaire Grenoble Alpes
hepatogastroenterologie, Boulevard De La Chantourne, Cs 10217 La Tronche, Grenoble Cedex 9
Centre Hospitalier Universitaire De Saint Etienne
hepatogastroenterologie, Avenue Albert Raimond, 42270, Saint-Priest-En-Jarez

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2023-03-24 2025-06-16 2023-03-28 2024-06-20

Application history

7 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2022-08-18 France Acceptable
2022-11-14
2022-11-15
2 SUBSTANTIAL MODIFICATION SM-1 2022-12-22 France Acceptable
2023-03-17
2023-03-22
3 SUBSTANTIAL MODIFICATION SM-2 2023-06-26 France Acceptable
2023-08-23
2023-09-25
4 SUBSTANTIAL MODIFICATION SM-3 2024-03-01 France Acceptable
2024-05-06
2024-05-14
5 SUBSTANTIAL MODIFICATION SM-4 2024-06-28 France Acceptable
2024-07-31
2024-07-31
6 SUBSTANTIAL MODIFICATION SM-5 2024-10-15 France Acceptable
2024-12-02
2024-12-02
7 SUBSTANTIAL MODIFICATION SM-6 2025-03-11 France Acceptable 2025-04-08