ME-401 combined with rituximab-bendamustine for high-risk and rituximab with a 1:1 randomization to ME-401 for low-risk follicular lymphoma as primary treatment: a phase II study – NLG-FL5 (Follicular lymphoma and ME-401: FLAME)

2022-501138-49-00 Protocol NLG-FL5 FLAME Therapeutic exploratory (Phase II) Ended

End 1 Dec 2022 · Status Ended · 1 EU/EEA countries · 7 sites · Protocol NLG-FL5 FLAME

Overview

Sponsor-declared trial summary

Phase Therapeutic exploratory (Phase II)
Status Ended
Participants planned 60
Countries 1
Sites 7

Follicular Lymphoma

Key facts

Sponsor
Karolinska University Hospital
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Hemic and Lymphatic Diseases [C15]
Trial duration
completed 1 Dec 2022
Decision date (initial)
2022-10-14
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Follicular Lymphoma

VersionLevelCodeTermSystem organ class
20.0 HLT 10016903 Follicle centre lymphomas follicular grade I II III 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Karolinska University Hospital

Sponsor organisation
Karolinska University Hospital
Address
Eugeniavagen 3
City
Solna
Postcode
171 64
Country
Sweden

Scientific contact point

Organisation
Karolinska University Hospital
Contact name
Coordinating Investigator

Public contact point

Organisation
Karolinska University Hospital
Contact name
Coordinating Investigator

Locations

1 EU/EEA country · 7 investigational sites

By country

CountryMS statusPlanned subjectsSites
Sweden Ended 60 7
Rest of world 0

Investigational sites

Sweden

7 sites · Ended
Nu Hospital Group-Vastra Goetalandsregionen
Uddevalla Hospital, Dept. of Hematology, Larketorpsvagen, 461 85, Trollhattan
Lanssjukhuset Kalmar Region Kalmar Lan
Dept. of Hematology, Lasarettsvagen 8, Kalmar S:t Johannes, Kalmar
Sahlgrenska University Hospital - Västra Götalandsregionen
undefined, Diagnosvagen 11, Harlanda, Gothenburg
Linkoping University Hospital Region Ostergotland
undefined, Universitetssjukhuset I Linkoping, 581 85, Linkoping
Karolinska University Hospital
Dept of Hematology, Eugeniavagen 3, 171 64, Solna
Uppsala University Hospital
Dept. of Immunology, Genetics and Pathology, Akademiska Sjukhuset, 751 85, Uppsala
Sankt Gorans Sjukhus
Dept. of Medicine, Sankt Goransplan 1, Vastermalm, Stockholm

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2022-06-28 Sweden Acceptable with conditions
2022-10-10
2022-10-14