Monocentric phase 1 dose-escalation study of siltuximab in combination with idarubicin and cytarabine chemotherapy in patients with poor prognosis acute myelogenous leukemia (AML): SILTUXILAM

2022-501171-14-00 Protocol RC22_0233 Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 13 Mar 2023 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol RC22_0233

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 12
Countries 1
Sites 1

adult patients with acute myeloblastic leukemia (AML) of poor prognosis first Line or Relapse

Key facts

Sponsor
Centre Hospitalier Universitaire De Nantes
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Hemic and Lymphatic Diseases [C15]
Trial duration
13 Mar 2023 → ongoing
Decision date (initial)
2022-11-28
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

adult patients with acute myeloblastic leukemia (AML) of poor prognosis first Line or Relapse

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Centre Hospitalier Universitaire De Nantes

Sponsor organisation
Centre Hospitalier Universitaire De Nantes
Address
5 Allee De L Ile Gloriette, Cs 69301 Cs 69301
City
Nantes Cedex 1
Postcode
44093
Country
France

Scientific contact point

Organisation
Centre Hospitalier Universitaire De Nantes
Contact name
Pierre PETERLIN

Public contact point

Organisation
Centre Hospitalier Universitaire De Nantes
Contact name
Pierre PETERLIN

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruiting 12 1
Rest of world 0

Investigational sites

France

1 site · Ongoing, recruiting
Centre Hospitalier Universitaire De Nantes
service d'hématologie clinique, 1 Place Alexis Ricordeau, 44000, Nantes

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2023-03-13 2023-03-16

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2022-08-31 France Acceptable
2022-11-28
2022-11-28
2 SUBSTANTIAL MODIFICATION SM-1 2023-03-15 France Acceptable
2023-04-21
2023-04-21
3 SUBSTANTIAL MODIFICATION SM-2 2025-02-24 France Acceptable
2025-03-19
2025-04-02