Randomised, crossover bioequivalence clinical trial of edoxaban 60 mg film-coated tablets, after a single oral dose administration to healthy volunteers under fasting conditions.

2022-502085-24-00 Protocol DC01EDO/1/22 Human pharmacology (Phase I) - Bioequivalence study Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol DC01EDO/1/22

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Authorised, recruitment pending
Participants planned 15
Countries 1
Sites 1

Edoxaban is used as antithrombotic agents, but it is a bioequivalence trial and the study population is healthy volunteers

Key facts

Sponsor
Biohorm S.L.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Decision date (initial)
2022-12-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Edoxaban is used as antithrombotic agents, but it is a bioequivalence trial and the study population is healthy volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Biohorm S.L.

Sponsor organisation
Biohorm S.L.
Address
Avinguda Del Cami Reial 51-57
City
Palau-Solita I Plegamans
Postcode
08184
Country
Spain

Scientific contact point

Organisation
Biohorm S.L.
Contact name
Iñaki Izquierdo Pulido

Public contact point

Organisation
Biohorm S.L.
Contact name
Daniel Peris González

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Authorised, recruitment pending 15 1
Rest of world 0

Investigational sites

Spain

1 site · Authorised, recruitment pending
Hospital Universitario De La Princesa
Clinical Pharmacology, Calle De Diego De Leon 62, 28006, Madrid

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2022-10-05 Spain Acceptable
2022-12-20
2022-12-22
2 SUBSTANTIAL MODIFICATION SM-1 2023-08-03 Spain Acceptable
2023-09-15
2023-09-15