DART (19-14434) Durvalumab (MEDI4736) After chemoRadioTherapy (DART) for NSCLC patients – a phase II translational and biomarker study investigating PDL1 positive and negative patients

2022-502640-12-01 Protocol ESR-19-14434 Phase I and Phase II (Integrated) - Other Ongoing, recruitment ended

Start 27 Sep 2024 · Status Ongoing, recruitment ended · 4 EU/EEA countries · 10 sites · Protocol ESR-19-14434

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - Other
Status Ongoing, recruitment ended
Participants planned 130
Countries 4
Sites 10

Non-small cell lung cancer (NSCLC)

Key facts

Sponsor
Oslo University Hospital Hf
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
27 Sep 2024 → ongoing
Decision date (initial)
2024-09-27
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2022-502640-12-01
EudraCT number
2019-002537-11
ClinicalTrials.gov
NCT04392504

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Non-small cell lung cancer (NSCLC)

VersionLevelCodeTermSystem organ class
20.0 SOC 10029104 Neoplasms benign malignant and unspecified (incl cysts and polyps) 2

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Oslo University Hospital Hf

Sponsor organisation
Oslo University Hospital Hf
Address
Taarnbygget, Kirkeveien 166 Kirkeveien 166
City
Oslo
Postcode
0450
Country
Norway

Scientific contact point

Organisation
Oslo University Hospital Hf
Contact name
Åslaug Helland

Public contact point

Organisation
Oslo University Hospital Hf
Contact name
Åslaug Helland

Locations

4 EU/EEA countries · 10 investigational sites

By country

CountryMS statusPlanned subjectsSites
Estonia Ongoing, recruitment ended 10 1
Finland Ongoing, recruitment ended 15 3
Lithuania Ongoing, recruitment ended 10 1
Norway Ongoing, recruitment ended 95 5
Rest of world 0

Investigational sites

Estonia

1 site · Ongoing, recruitment ended
North Estonia Medical Centre Foundation
Department of chemotherapy, clinic of oncology and haematology, J. Sutiste Tee 19, Mustamae Linnaosa, Tallinn

Finland

3 sites · Ongoing, recruitment ended
Turku University Hospital
Oncology department, Hameentie 11, 20520, Turku
Oulu University Hospital
department of oncology, Kajaanintie 50, 90220, Oulu
Tampere University Hospital
Department of oncology, Teiskontie 35, 33520, Tampere

Lithuania

1 site · Ongoing, recruitment ended
Vilnius University Hospital
Oncology Department, Santariskiu G. 1, Vilniaus M. Sav., Vilnius

Norway

5 sites · Ongoing, recruitment ended
St. Olavs Hospital HF
Department of cancer research and molecular medicine, P. O. Box 3250, Torgarden, Trondheim
Helse Bergen HF
Avdeling for kreftbehandling og medisinsk fysikk, P. O. Box 1400, 5021, Bergen
Oslo University Hospital HF
Department of oncology, Taarnbygget, Kirkeveien 166, Oslo
University Hospital Of North Norway HF
Department of oncology and Department of pulmology, P. O. Box 100, 9038, Tromsoe
Stavanger University Hospital
Department of pulmonary medicine, Postboks 8100, 4068, Stavanger

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Estonia 2024-09-27 2024-09-27 2024-12-15
Finland 2024-09-27 2024-09-27 2024-12-15
Lithuania 2024-10-23 2024-10-23 2024-12-15
Norway 2024-09-27 2024-09-27 2024-12-15

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-08-27 Norway Acceptable
2024-09-26
2024-09-27