A Phase 1b Study to Characterize the Safety and Tolerability of TEV-53408 in Adults with Celiac Disease

2022-502817-27-00 Protocol TV53408-IMM-10197 Human pharmacology (Phase I) - Other Ended

Start 15 Mar 2024 · End 9 Oct 2025 · Status Ended · 1 EU/EEA countries · 2 sites · Protocol TV53408-IMM-10197

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 20
Countries 1
Sites 2

Celiac disease

Key facts

Sponsor
Teva Branded Pharmaceutical Products R&D LLC
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Digestive System Diseases [C06]
Trial duration
15 Mar 2024 → 9 Oct 2025
Decision date (initial)
2023-10-19
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Celiac disease

VersionLevelCodeTermSystem organ class
20.0 LLT 10007864 Celiac disease 10017947

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Teva Branded Pharmaceutical Products R&D LLC

Sponsor organisation
Teva Branded Pharmaceutical Products R&D LLC
Address
145 Brandywine Parkway
City
West Chester
Postcode
19380-4245
Country
United States

Scientific contact point

Organisation
Teva Branded Pharmaceutical Products R&D Inc.
Contact name
Medical information

Public contact point

Organisation
Teva Branded Pharmaceutical Products R&D Inc.
Contact name
Medical information

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Finland Ended 6 2
Rest of world
United States, Australia
14

Investigational sites

Finland

2 sites · Ended
Pirkanmaan hyvinvointialue
Tays Research Services, Arvo Ylpön katu 6, Finn-Medi 1, 33521 Tampere, Finland, P. O. Box 272, 33101, Tampere
Clinical Research Services Turku Oy
N/A, Itainen Pitkakatu 4b, 20520, Turku

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Finland 2024-03-15 2025-10-08 2024-04-30 2024-06-14

Application history

10 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-07-07 Finland Acceptable
2023-10-17
2023-10-19
2 SUBSTANTIAL MODIFICATION SM-1 2023-11-07 Finland Acceptable 2024-01-16
3 NON SUBSTANTIAL MODIFICATION NSM-1 2024-01-19 Finland Acceptable 2024-01-19
4 SUBSTANTIAL MODIFICATION SM-2 2024-02-16 Finland Acceptable
2024-03-25
2024-03-26
5 NON SUBSTANTIAL MODIFICATION NSM-2 2024-04-16 Finland Acceptable
2024-03-25
2024-04-16
6 NON SUBSTANTIAL MODIFICATION NSM-3 2024-05-24 Finland Acceptable
2024-03-25
2024-05-24
7 NON SUBSTANTIAL MODIFICATION NSM-4 2025-02-27 Finland Acceptable
2024-03-25
2025-02-27
8 NON SUBSTANTIAL MODIFICATION NSM-5 2025-03-24 Finland Acceptable
2024-03-25
2025-03-24
9 NON SUBSTANTIAL MODIFICATION NSM-6 2025-06-02 Finland Acceptable
2024-03-25
2025-06-02
10 NON SUBSTANTIAL MODIFICATION NSM-7 2025-09-10 Finland Acceptable
2024-03-25
2025-09-10