An open-label, multi-center, dose-escalation Phase Ib study to determine the recommended phase 2 dose of APN401 in patients with advanced solid tumors

2023-504281-34-00 Protocol APN401-104 Human pharmacology (Phase I) - Other Ended

Start 22 Aug 2023 · End 20 Nov 2024 · Status Ended · 1 EU/EEA countries · 5 sites · Protocol APN401-104

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 12
Countries 1
Sites 5

Adult patients with advanced solid tumors

Key facts

Sponsor
Invios GmbH
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
22 Aug 2023 → 20 Nov 2024
Decision date (initial)
2023-07-24
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Adult patients with advanced solid tumors

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Invios GmbH

Sponsor organisation
Invios GmbH
Address
Campus-Vienna-Biocenter 5, Landstrasse Landstrasse
City
Vienna
Postcode
1030
Country
Austria

Scientific contact point

Organisation
Invios GmbH
Contact name
Romana Gugenberger

Public contact point

Organisation
Invios GmbH
Contact name
Romana Gugenberger

Locations

1 EU/EEA country · 5 investigational sites

By country

CountryMS statusPlanned subjectsSites
Austria Ended 12 5
Rest of world 0

Investigational sites

Austria

5 sites · Ended
Medizinische Universitaet Innsbruck
Department of Internal Medicine V, Hematology and Oncology, Anichstrasse 35, 6020, Innsbruck
Allgemeines Krankenhaus Der Stadt Wien Universitatskliniken
Department for Transfusion Medicine and Cell Therapy, Waehringer Guertel 18-20, Alsergrund, Vienna
SCRI CCCIT Ges.m.b.H.
III. Med. Department of Hematology,Medical Oncology,Hemostaseology,Infectious Disease&Rheumatology, Muellner Hauptstrasse 48, 5020, Salzburg
Ordensklinikum Linz GmbH
Barmherzige Schwestern, Department of HNO/Head & Neck Surgery, Seilerstaette 4, 4020, Linz
Ordensklinikum Linz GmbH
Elisabethinen, Department of Hematology & Oncology, Fadingerstrasse 1, 4020, Linz

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Austria 2023-08-22 2024-11-20 2023-08-22 2024-04-03

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-03-31 Austria Acceptable with conditions
2023-07-17
2023-07-24
2 SUBSTANTIAL MODIFICATION SM-1 2024-02-05 Austria Acceptable
2024-04-02
2024-04-08