A Phase 1, Double-blind, Randomized, Placebo-controlled, First-in-Human Study of Orally Administered DF-006 to Evaluate the Safety, Tolerability, and Pharmacokinetics After a Single Dose and Multiple Doses of Orally Administered DF-006 in Healthy Subjects (Part 1 and Part 2) and in Chronic Hepatitis B Patients (Part 3). Protocol Number Df-006-1001

2023-504288-18-00 Protocol DF-006-1001 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 2 EU/EEA countries · 2 sites · Protocol DF-006-1001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 119
Countries 2
Sites 2

Chronic Hepatitis B

Key facts

Sponsor
Zhejiang Yaoyuan Biotechnology Co. Ltd.
Participant type
Patients
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Virus Diseases [C02]
Decision date (initial)
2024-04-17
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Chronic Hepatitis B

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Zhejiang Yaoyuan Biotechnology Co. Ltd.

Sponsor organisation
Zhejiang Yaoyuan Biotechnology Co. Ltd.
Address
Building D7, 555 Chuangye Road, Pinghu 555 Chuangye Road Pinghu
City
Jiaxing
Postcode
314203
Country
China

Scientific contact point

Organisation
Zhejiang Yaoyuan Biotechnology Co. Ltd.
Contact name
Eshwari Kovoor

Public contact point

Organisation
Zhejiang Yaoyuan Biotechnology Co. Ltd.
Contact name
Eshwari Kovoor

Locations

2 EU/EEA countries · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Authorised, recruitment pending 5 1
Romania Authorised, recruitment pending 7 1
Rest of world
Korea, Democratic People's Republic of, Ukraine, China, Taiwan, Moldova, Republic of
107

Investigational sites

Bulgaria

1 site · Authorised, recruitment pending
Multiprofile Hospital for Active Treatment Sveta Sofia
Internal Medicine, Bulevard Bilgariya 104, 1404, Sofiya

Romania

1 site · Authorised, recruitment pending
Spitalul Clinic Judetean De Urgenta Cluj
Ophthalmology Building, 1st floor, wards 33, 34, and 35, Strada Clinicilor 3-5, 400006, Cluj-Napoca

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-12-05 Romania Acceptable
2024-04-15
2024-04-16