A study to test how either a capsule or a tablet with NDec (Decitabine and Tetrahydrouridine) works in the body of healthy people

2023-504582-22-00 Protocol NN7533-7587 Human pharmacology (Phase I) - First administration to humans Not authorised

Status Not authorised · 1 EU/EEA countries · 1 sites · Protocol NN7533-7587

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Not authorised
Participants planned 48
Countries 1
Sites 1

Sickle Cell Disease

Key facts

Sponsor
Novo Nordisk A/S
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Hemic and Lymphatic Diseases [C15]
Decision date (initial)
2023-10-17
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
No

External identifiers

EU CT number
2023-504582-22-00
WHO UTN
U1111-1285-7491

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Sickle Cell Disease

VersionLevelCodeTermSystem organ class
21.0 PT 10040644 Sickle cell disease 100000004850

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Novo Nordisk A/S

Sponsor organisation
Novo Nordisk A/S
Address
Novo Alle 1
City
Bagsvaerd
Postcode
2880
Country
Denmark

Scientific contact point

Organisation
Novo Nordisk A/S
Contact name
EU Submission Hub

Public contact point

Organisation
Novo Nordisk A/S
Contact name
EU Submission Hub

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Not authorised 48 1
Rest of world 0

Investigational sites

Germany

1 site · Not authorised
PROFIL Institut fuer Stoffwechselforschung GmbH
N/A, Hellersbergstrasse 9, Hammfeld, Neuss

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-07-24 Germany Not acceptable
2023-10-12
2023-10-17