A bioequivalence vasoconstriction study comparing two clobetasol propionate 0.5 mg/g ointments after skin application in healthy adult human subjects

2023-504707-87-00 Protocol CO/BE/06/2022 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 20 Nov 2023 · End 12 Feb 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol CO/BE/06/2022

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 100
Countries 1
Sites 1

Localized, therapy-resistant inflammatory skin diseases, for which the use of topical corticosteroids with very high potency is indicated.

Key facts

Sponsor
BELUPO lijekovi i kozmetika d.d.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Skin and Connective Tissue Diseases [C17]
Trial duration
20 Nov 2023 → 12 Feb 2024
Decision date (initial)
2023-09-11
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Localized, therapy-resistant inflammatory skin diseases, for which the use of topical corticosteroids with very high potency is indicated.

VersionLevelCodeTermSystem organ class
21.1 PT 10081154 Skin lesion inflammation 100000004858
21.0 LLT 10062249 Skin inflammation 10040785

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

BELUPO lijekovi i kozmetika d.d.

Sponsor organisation
BELUPO lijekovi i kozmetika d.d.
Address
Ulica Danica 5
City
Koprivnica
Postcode
48000
Country
Croatia

Scientific contact point

Organisation
BELUPO lijekovi i kozmetika d.d.
Contact name
Tatjana Ajhler Duretek, MD, MSc

Public contact point

Organisation
BELUPO lijekovi i kozmetika d.d.
Contact name
Tatjana Ajhler Duretek, MD, MSc

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Poland Ended 100 1
Rest of world 0

Investigational sites

Poland

1 site · Ended
Mtz Clinical Research Powered By Pratia
Phase I unit, Ul. Gładka 22, 02-172, Warsaw

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Poland 2023-11-20 2024-02-12 2023-11-27 2024-02-12

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-05-18 Poland Acceptable with conditions
2023-09-04
2023-09-11
2 SUBSTANTIAL MODIFICATION SM-1 2023-09-29 Poland Acceptable
2023-11-13
2023-11-15