A Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR) - targeting, Bifunctional Antibody-fusion molecule, in Subjects with Unresectable, Locally Advanced, or Metastatic Solid Tumors that are Antigen-Rich (START-001)

2023-505334-10-00 Protocol CP-START-001 Phase I and Phase II (Integrated) - First administration to humans Not authorised

Status Not authorised · 2 EU/EEA countries · 2 sites · Protocol CP-START-001

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - First administration to humans
Status Not authorised
Participants planned 271
Countries 2
Sites 2

Unresectable, Locally Advanced, or Metastatic Solid Tumors

Key facts

Sponsor
Marengo Therapeutics Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2024-01-15
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Unresectable, Locally Advanced, or Metastatic Solid Tumors

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Marengo Therapeutics Inc.

Sponsor organisation
Marengo Therapeutics Inc.
Address
840 Memorial Drive Floor 4
City
Cambridge
Postcode
02139-3771
Country
United States

Scientific contact point

Organisation
Marengo Therapeutics Inc.
Contact name
Ke Liu

Public contact point

Organisation
Marengo Therapeutics Inc.
Contact name
Ke Liu

Locations

2 EU/EEA countries · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Not authorised 23 1
Spain Not authorised 23 1
Rest of world
Canada, United States
225

Investigational sites

France

1 site · Not authorised
Institut Gustave Roussy
DITEP, 114 Rue Edouard Vaillant, 94800, Villejuif

Spain

1 site · Not authorised
Hospital Universitari Vall D Hebron
Oncology, Edificio Materno-Infantil, Passeig De La Vall D'hebron 119-129, Barcelona

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-09-01 France Not acceptable
2024-01-10
2024-01-11