A study to investigate the mass balance, absolute bioavailability (BA), pharmacokinetics (PK), and metabolism of a single oral dose 60 mg [14C]-alogabat and an IV microdose of 100 μg [13C]-alogabat

2023-506044-16-00 Protocol BP41817 Human pharmacology (Phase I) - Other Ended

Start 14 Dec 2023 · End 15 Mar 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol BP41817

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 8
Countries 1
Sites 1

There is no medical condition being investigated.

Key facts

Sponsor
F. Hoffmann-La Roche AG
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male
Therapeutic area
Diseases [C] - Nervous System Diseases [C10], Psychiatry and Psychology [F] - Behavioral Disciplines and Activities [F04]
Trial duration
14 Dec 2023 → 15 Mar 2024
Decision date (initial)
2023-10-26
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

There is no medical condition being investigated.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

F. Hoffmann-La Roche AG

Sponsor organisation
F. Hoffmann-La Roche AG
Address
Grenzacherstrasse 124
City
Basel
Postcode
4058
Country
Switzerland

Scientific contact point

Organisation
F. Hoffmann-La Roche AG
Contact name
Trial Information Support Line - TISL

Public contact point

Organisation
F. Hoffmann-La Roche AG
Contact name
Trial Information Support Line - TISL

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ended 8 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ended
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2023-12-14 2024-03-15 2023-12-14 2024-01-04

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-09-22 Netherlands Acceptable
2023-10-26
2023-10-26
2 SUBSTANTIAL MODIFICATION SM-1 2023-11-14 Netherlands Acceptable
2023-12-01
2023-12-01