A study to test whether multiple doses of BI 456906 have an effect on cardiac safety in people with overweight or obesity.

2023-506375-10-00 Protocol 1404-0011 Human pharmacology (Phase I) - Other Ended

Start 4 Mar 2024 · End 22 Oct 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol 1404-0011

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 110
Countries 1
Sites 1

Healthy volunteer trial

Key facts

Sponsor
Boehringer Ingelheim International GmbH
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
4 Mar 2024 → 22 Oct 2025
Decision date (initial)
2024-01-12
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2023-506375-10-00
WHO UTN
U1111-1295-4369

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy volunteer trial

VersionLevelCodeTermSystem organ class
21.0 LLT 10053349 Pharmacokinetic study 10022891

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Boehringer Ingelheim International GmbH

Sponsor organisation
Boehringer Ingelheim International GmbH
Address
Binger Strasse 173
City
Ingelheim Am Rhein
Postcode
55216
Country
Germany

Scientific contact point

Organisation
Boehringer Ingelheim International GmbH
Contact name
CT Disclosure & Data Transparency

Public contact point

Organisation
Boehringer Ingelheim International GmbH
Contact name
CT Disclosure & Data Transparency

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 110 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
CRS Clinical Research Services Management GmbH
Phase I Unit, Grenadierstrasse 1, Neckarstadt, Mannheim

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2024-03-04 2025-10-22 2024-03-13 2025-02-13

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-10-26 Germany Acceptable
2024-01-09
2024-01-12
2 SUBSTANTIAL MODIFICATION SM-1 2024-03-01 Germany Acceptable
2024-03-25
2024-03-28
3 SUBSTANTIAL MODIFICATION SM-2 2024-06-20 Germany Acceptable
2024-07-12
2024-07-16
4 SUBSTANTIAL MODIFICATION SM-3 2024-09-16 Germany Acceptable
2024-10-01
2024-10-09