An open-label, single-center study to evaluate the safety and test-retest characteristics of [11C]MODAG-005 as PET radioligand for imaging pathological alpha-synuclein deposition in the brains of patients with Parkinson’s disease (PD) or Multiple System Atrophy (MSA) compared to age-matched healthy controls (AMHC)

2023-506965-72-00 Protocol MODAG-005-P1-01 Human pharmacology (Phase I) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol MODAG-005-P1-01

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruitment pending
Participants planned 28
Countries 1
Sites 1

Parkinson Disease

Key facts

Sponsor
Modag GmbH
Participant type
Patients, Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Not possible to specify, Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01], Diseases [C] - Nervous System Diseases [C10]
Decision date (initial)
2026-05-04
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Parkinson Disease

VersionLevelCodeTermSystem organ class
20.0 PT 10061536 Parkinson's disease 100000004852
21.1 PT 10064060 Multiple system atrophy 100000004852
26.0 LLT 10088820 Clinical trial healthy volunteer 100000004848

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Modag GmbH

Sponsor organisation
Modag GmbH
Address
Mikro-Forum-Ring 3
City
Wendelsheim
Postcode
55234
Country
Germany

Scientific contact point

Organisation
Modag GmbH
Contact name
Prof. Dr. Levin

Public contact point

Organisation
Modag GmbH
Contact name
Prof. Dr. Levin

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Authorised, recruitment pending 28 1
Rest of world 0

Investigational sites

Germany

1 site · Authorised, recruitment pending
Universitätsklinikum Tübingen
Department Radiologie, Ottfried-Müller-Str. 10, 72076, Tübingen

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-02-13 Germany Acceptable
2026-04-20
2026-05-04