In situ injection of anti-angiogenics in patients with brain arteriovenous malformations not eligible for exclusion treatment: phase I trial (BLITZ)

2023-506991-28-00 Protocol APHP 211033 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 7 sites · Protocol APHP 211033

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 20
Countries 1
Sites 7

Cardiology and vascular disease

Key facts

Sponsor
Assistance Publique Hopitaux De Paris
Participant type
Patients
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14], Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Decision date (initial)
2025-01-27
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Cardiology and vascular disease

VersionLevelCodeTermSystem organ class
20.0 SOC 10010331 Congenital familial and genetic disorders 21
26.0 PT 10056371 Cerebrovascular arteriovenous malformation 100000004850

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Assistance Publique Hopitaux De Paris

Sponsor organisation
Assistance Publique Hopitaux De Paris
Address
Porte 23, 1 Avenue Claude Vellefaux 1 Avenue Claude Vellefaux
City
Paris Cedex 10
Postcode
75475
Country
France

Scientific contact point

Organisation
Assistance Publique Hopitaux De Paris
Contact name
Investigateur coordonnateur

Public contact point

Organisation
Assistance Publique Hopitaux De Paris
Contact name
Investigateur coordonnateur

Locations

1 EU/EEA country · 7 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 20 7
Rest of world 0

Investigational sites

France

7 sites · Authorised, recruitment pending
Pellegrin Hospital
Neurochirurgie, Place Amelie Raba Leon, 33000, Bordeaux
Hopitaux Universitaires Pitie Salpetriere
Neurochirurgie, 47 To 83 Boulevard De L Hopital, 75013, Paris
Groupe Hospitalier Universitaire Paris Psychiatrie Et Neuroscience
Neuroradiologie interventionnelle, 1 Rue Cabanis, 75014, Paris
Centre Hospitalier Et Universitaire De Limoges
Neuroradiologie, 2 Avenue Martin Luther King, 87000, Limoges
CHRU De Nancy
Neuroradiologie interventionnelle, 29 Avenue Du Mal De Lattre De Tassigny, 54000, Nancy
Hopitaux Universitaires Pitie Salpetriere
Neuroradiologie interventionnelle, 47 To 83 Boulevard De L Hopital, 75013, Paris
Pellegrin Hospital
Neuroradiologie interventionnelle, Place Amelie Raba Leon, 33000, Bordeaux

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-10-22 France Acceptable
2025-01-27
2025-01-27
2 SUBSTANTIAL MODIFICATION SM-1 2025-11-18 France Acceptable
2025-12-11
2025-12-23
3 NON SUBSTANTIAL MODIFICATION NSM-1 2026-03-31 France Acceptable
2025-12-11
2026-03-31