Double-Blind, Randomized, Placebo-Controlled, Phase 1b, Pharmacodynamic Trial of TEV-56192 Following a Single Intravenous Administration in Healthy Participants

2023-507018-29-00 Protocol TV56192-PD-10191 Human pharmacology (Phase I) - Other Ended

Start 5 Mar 2024 · End 22 Nov 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol TV56192-PD-10191

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 48
Countries 1
Sites 1

Pruritus

Key facts

Sponsor
Teva Branded Pharmaceutical Products R&D Inc.
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Skin and Connective Tissue Diseases [C17]
Trial duration
5 Mar 2024 → 22 Nov 2024
Decision date (initial)
2024-02-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Pruritus

VersionLevelCodeTermSystem organ class
24.1 PT 10037087 Pruritus 100000004858

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Teva Branded Pharmaceutical Products R&D Inc.

Sponsor organisation
Teva Branded Pharmaceutical Products R&D Inc.
Address
145 Brandywine Parkway
City
West Chester
Postcode
19380-4245
Country
United States

Scientific contact point

Organisation
Teva Branded Pharmaceutical Products R&D Inc.
Contact name
Medical Information

Public contact point

Organisation
Teva Branded Pharmaceutical Products R&D Inc.
Contact name
Medical Information

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Denmark Ended 48 1
Rest of world 0

Investigational sites

Denmark

1 site · Ended
Sanos A/S
Sanos Clinic, Herlev Hovedgade 82, 2730, Herlev

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Denmark 2024-03-05 2024-11-22 2024-03-18 2024-09-20

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-11-23 Denmark Acceptable
2024-02-22
2024-02-22
2 NON SUBSTANTIAL MODIFICATION NSM-1 2024-03-05 Denmark Acceptable
2024-02-22
2024-03-05
3 SUBSTANTIAL MODIFICATION SM-1 2024-05-07 Denmark Acceptable 2024-05-15
4 SUBSTANTIAL MODIFICATION SM-2 2024-07-12 Denmark Acceptable
2024-07-31
2024-08-06