A randomized double-blind placebo-controlled phase 1 study on the safety, tolerability and pharmacokinetics/-dynamics of escalating single intravenous doses of AK1967 (Procizumab) in healthy male volunteers

2023-507035-37-00 Human pharmacology (Phase I) - First administration to humans Ended

Start 11 Mar 2024 · End 5 Jul 2024 · Status Ended · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ended
Participants planned 24
Countries 1
Sites 1

Circulatory shock

Key facts

Sponsor
4TEEN4 Pharmaceuticals GmbH
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Trial duration
11 Mar 2024 → 5 Jul 2024
Decision date (initial)
2024-02-21
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Circulatory shock

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

4TEEN4 Pharmaceuticals GmbH

Sponsor organisation
4TEEN4 Pharmaceuticals GmbH
Address
Neuendorfstrasse 15 A
City
Hennigsdorf
Postcode
16761
Country
Germany

Scientific contact point

Organisation
4TEEN4 Pharmaceuticals GmbH
Contact name
Karine Bourgeois

Public contact point

Organisation
4TEEN4 Pharmaceuticals GmbH
Contact name
Karine Bourgeois

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ended 24 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ended
Radboud universitair medisch centrum / RADBOUDUMC
Intensive Care, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2024-03-11 2024-07-05 2024-03-11 2024-06-06

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-11-20 Netherlands Acceptable
2024-02-21
2024-02-21