A clinical trial for patients with relapsed or refractory multiple myeloma, using an experimental drug called ISB 2001 for the first time in humans

2023-507071-21-01 Protocol ISB 2001-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 14 Aug 2025 · Status Ongoing, recruiting · 4 EU/EEA countries · 15 sites · Protocol ISB 2001-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 200
Countries 4
Sites 15

Relapsed/Refractory Multiple Myeloma

Key facts

Sponsor
IGI Therapeutics S.A.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Hemic and Lymphatic Diseases [C15]
Trial duration
14 Aug 2025 → ongoing
Decision date (initial)
2025-06-16
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
Yes

External identifiers

EU CT number
2023-507071-21-01
ClinicalTrials.gov
NCT05862012

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Relapsed/Refractory Multiple Myeloma

VersionLevelCodeTermSystem organ class
21.1 LLT 10067095 Multiple myeloma progression 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

IGI Therapeutics S.A.

Sponsor organisation
IGI Therapeutics S.A.
Address
Rue Du Puits-Godet 8
City
Neuchatel
Postcode
2000
Country
Switzerland

Scientific contact point

Organisation
IGI Therapeutics S.A.
Contact name
Biologics Manufacturing/ Process Sciences entity

Public contact point

Organisation
IGI Therapeutics S.A.
Contact name
Biologics Manufacturing/ Process Sciences entity

Locations

4 EU/EEA countries · 15 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruiting 25 5
Italy Authorised, recruiting 15 3
Norway Ongoing, recruiting 20 1
Spain Ongoing, recruiting 25 6
Rest of world
Japan, United States, United Kingdom, India, Australia
115

Investigational sites

France

5 sites · Ongoing, recruiting
Centre Hospitalier Universitaire De Poitiers
Hematology, 2 Rue De La Miletrie, 86000, Poitiers
Centre Hospitalier Universitaire De Lille
Maladies du sang, Rue Michel Polonowski, 59000, Lille
Hopital Saint Antoine
Hematology, 184 Rue Du Faubourg Saint Antoine, 75571, Paris Cedex 12
Centre Hospitalier Universitaire De Nantes
Hematology, 1 Place Alexis Ricordeau, 44000, Nantes
Assistance Publique Hopitaux De Paris
Haematology, 47 Boulevard De L Hopital, 75651, Paris Cedex 13

Italy

3 sites · Authorised, recruiting
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
S.C. Hematology, Via Francesco Sforza 28, 20122, Milan
Humanitas Mirasole S.p.A.
U.O di Oncologia Medica ed Ematologia, Via Alessandro Manzoni 56, 20089, Rozzano
Azienda Socio Sanitaria Territoriale Degli Spedali Civili Di Brescia
U.O.C. Ematologia, Piazzale Spedali Civili 1, 25123, Brescia

Norway

1 site · Ongoing, recruiting
Oslo University Hospital HF
Oslo Myeloma Center, Taarnbygget, Kirkeveien 166, Oslo

Spain

6 sites · Ongoing, recruiting
Hospital Universitario Fundacion Jimenez Diaz
Hematology, Avenida De Los Reyes Catolicos 2, 28040, Madrid
Hospital Clinic De Barcelona
Hematology, Calle Villarroel 170, 08036, Barcelona
Institut Catala D'oncologia
Hematology, Carretera Canyet S/n, 08916, Badalona
Hospital Universitario De Salamanca
Hematology, Paseo De San Vicente 58-182, 37007, Salamanca
Clinica Universidad De Navarra
Hematology, Pio XII Etorbidea 36, 31008, Pamplona
Hospital Universitario Hm Sanchinarro
Hematology, Calle Ona 10, 28050, Madrid

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2025-08-14 2025-09-26
Italy 2025-09-26
Norway 2025-08-26 2025-09-24
Spain 2025-08-29 2025-11-27

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-02-28 France Acceptable
2025-06-16
2025-06-16
2 SUBSTANTIAL MODIFICATION SM-1 2025-08-05 France Acceptable
2025-09-04
2025-09-04
3 SUBSTANTIAL MODIFICATION SM-2 2025-09-18 France Acceptable
2025-11-26
2025-11-26
4 SUBSTANTIAL MODIFICATION SM-3 2026-01-21 France Acceptable
2026-04-07
2026-04-07
5 NON SUBSTANTIAL MODIFICATION NSM-1 2026-06-01 France Acceptable
2026-04-07
2026-06-01