An open-label cocktail drug-drug interaction (DDI) clinical study to assess the effect of multiple oral dosing with leniolisib on the pharmacokinetics (PK) of caffeine, midazolam, rosuvastatin, furosemide, and metformin in healthy subjects

2023-507134-25-00 Protocol LE 5101 Human pharmacology (Phase I) - Other Ended

Start 29 Jan 2024 · End 2 Apr 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol LE 5101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 20
Countries 1
Sites 1

Activated Phosphoinositide 3-Kinase Delta Syndrome

Key facts

Sponsor
Pharming Technologies B.V.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Immune System Diseases [C20]
Trial duration
29 Jan 2024 → 2 Apr 2024
Decision date (initial)
2024-01-08
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Activated Phosphoinositide 3-Kinase Delta Syndrome

VersionLevelCodeTermSystem organ class
20.0 PT 10078281 Activated PI3 kinase delta syndrome 100000004850

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Pharming Technologies B.V.

Sponsor organisation
Pharming Technologies B.V.
Address
Darwinweg 24
City
Leiden
Postcode
2333 CR
Country
Netherlands

Scientific contact point

Organisation
Pharming Technologies B.V.
Contact name
Clinical Department

Public contact point

Organisation
Pharming Technologies B.V.
Contact name
Clinical Department

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 20 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
CRS Clinical Research Services Mannheim GmbH
Clinincal Pharmacology Unit, Grenadierstrasse 1, Neckarstadt, Mannheim

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2024-01-29 2024-04-02 2024-01-29 2024-02-20

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-10-11 Germany Acceptable
2024-01-05
2024-01-08