First in human study of the infusion of ARI0003 cells in relapsed/refractory to treatment B-cell aggressive lymphoma

2023-507213-97-00 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 9 May 2024 · Status Ongoing, recruiting · 1 EU/EEA countries · 9 sites

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 52
Countries 1
Sites 9

Relapsed/refractory B-cell aggressive lymphoma

Key facts

Sponsor
Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
9 May 2024 → ongoing
Decision date (initial)
2024-01-08
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Relapsed/refractory B-cell aggressive lymphoma

VersionLevelCodeTermSystem organ class
21.0 LLT 10007995 Centroblastic lymphoma stage III 10029104
20.1 PT 10079945 Cutaneous lymphoma 100000004864
21.0 PT 10006599 Burkitt's lymphoma refractory 100000004864
21.1 LLT 10042355 Subcutaneous panniculitic T-cell lymphoma (Provisional subtype) stage IV 10029104
20.1 LLT 10080211 T-cell/histiocyte-rich large B-cell lymphoma 10029104
21.0 PT 10006598 Burkitt's lymphoma recurrent 100000004864
21.1 PT 10008958 Chronic lymphocytic leukaemia 100000004864
21.0 PT 10036710 Primary mediastinal large B-cell lymphoma 100000004864
21.1 PT 10065857 Primary effusion lymphoma 100000004864
21.1 PT 10065039 Plasmablastic lymphoma 100000004864
21.0 LLT 10069643 Intravascular large B-cell lymphoma 10029104
20.1 PT 10080215 High-grade B-cell lymphoma 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer

Sponsor organisation
Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer
Address
Calle Rosellon 149-153
City
Barcelona
Postcode
08036
Country
Spain

Scientific contact point

Organisation
Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer
Contact name
Clinical Trials Unit

Public contact point

Organisation
Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer
Contact name
Clinical Trials Unit

Locations

1 EU/EEA country · 9 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Ongoing, recruiting 52 9
Rest of world 0

Investigational sites

Spain

9 sites · Ongoing, recruiting
University Clinical Hospital Virgen De La Arrixaca
Hematology, Carretera De Cartagena Sn, El Palmar, Murcia
Hospital Universitario Central De Asturias
Hematologia y hemoterapia, Avenida De Roma S/n, 33011, Oviedo
Hospital Universitario De Salamanca
Hematology, Paseo De San Vicente 58-182, 37007, Salamanca
University Hospital Son Espases
Hematology, Carretera Valldemossa 79, 07120, Palma
Complexo Hospitalario Universitario De Santiago
Hematology, Calle Choupana Da S/n, 15706, Santiago De Compostela
Hospital Universitario Ramon Y Cajal
Hematology, Carretera Del Colmenar Viejo Km 9 100, Por El Pardo, Madrid
Hospital Clinic De Barcelona
Hematology, Calle Villarroel 170, 08036, Barcelona
Ico L'hospitalet Hospital Duran I Reynals
Hematology, Avinguda de la Granvia de l'hospitalet 199-203, 08908, Barcelona
Institut Catala D'oncologia
Hematology, Carretera Canyet S/n, 08916, Badalona

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Spain 2024-05-09 2024-05-27

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-09-19 Spain Acceptable
2023-12-20
2024-01-08
2 SUBSTANTIAL MODIFICATION SM-1 2025-02-14 Spain Acceptable
2025-04-30
2025-05-07