A multicenter, Phase 1b, double-blind, placebo-controlled study to evaluate the safety and tolerability, and the efficacy of si-544 in adults with psoriasis vulgaris or psoriatic arthritis

2023-507393-40-00 Protocol SEL-002 Human pharmacology (Phase I) - Other Ended

Start 12 Dec 2023 · End 23 Jun 2025 · Status Ended · 1 EU/EEA countries · 4 sites · Protocol SEL-002

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 45
Countries 1
Sites 4

psoriasis vulgaris

Key facts

Sponsor
selectION Therapeutics GmbH, selectION Therapeutics GmbH
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Skin and Connective Tissue Diseases [C17]
Trial duration
12 Dec 2023 → 23 Jun 2025
Decision date (initial)
2023-12-07
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2023-507393-40-00
WHO UTN
U1111-1295-8160
ClinicalTrials.gov
NCT06191042

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

psoriasis vulgaris

VersionLevelCodeTermSystem organ class
21.0 LLT 10037160 Psoriatic arthritis 10028395
20.0 LLT 10050576 Psoriasis vulgaris 10040785

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

selectION Therapeutics GmbH

Sponsor organisation
selectION Therapeutics GmbH
Address
Am Klopferspitz 19, Martinsried Martinsried
City
Planegg
Postcode
82152
Country
Germany

Scientific contact point

Organisation
selectION Therapeutics GmbH
Contact name
selectION Therapeutics GmbH Clinical Trial Information

Public contact point

Organisation
selectION Therapeutics GmbH
Contact name
selectION Therapeutics GmbH Clinical Trial Information

selectION Therapeutics GmbH

Sponsor organisation
selectION Therapeutics GmbH
Address
Am Klopferspitz 19, Martinsried Martinsried
City
Planegg
Postcode
82152
Country
Germany

Locations

1 EU/EEA country · 4 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 45 4
Rest of world 0

Investigational sites

Germany

4 sites · Ended
Fachaerztliche Gemeinschaftspraxis fuer Dermatologie Und Venerologie Allergologie Umweltmedizin Lasermedizin GbR
n.a., Am Bahnhof 1, Mahlow, Blankenfelde-Mahlow
Eurofins bioskin GmbH
n.a., Messberg 4, Hamburg-Altstadt, Hamburg
Thermalsole und Schwefelbad Bentheim GmbH
Fachabteilung Dermatologie, Am Bade 1, 48455, Bad Bentheim
Emovis GmbH
n.a., Bezirk Charlottenburg Wilmersdorf, Wilmersdorfer Strasse 79, Berlin

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2023-12-12 2025-06-23 2024-01-22 2025-03-17

Application history

8 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-10-04 Germany Acceptable
2023-12-05
2023-12-07
2 SUBSTANTIAL MODIFICATION SM-1 2024-04-12 Germany Acceptable
2024-05-13
2024-05-14
3 SUBSTANTIAL MODIFICATION SM-2 2024-08-09 Germany Acceptable
2024-08-29
2024-09-23
4 SUBSTANTIAL MODIFICATION SM-3 2024-10-10 Germany Acceptable
2024-10-30
2024-10-31
5 NON SUBSTANTIAL MODIFICATION NSM-6 2024-11-12 Germany Acceptable
2024-10-30
2024-11-12
6 NON SUBSTANTIAL MODIFICATION NSM-7 2025-01-17 Germany Acceptable
2024-10-30
2025-01-17
7 NON SUBSTANTIAL MODIFICATION NSM-8 2025-03-19 Germany Acceptable
2024-10-30
2025-03-19
8 NON SUBSTANTIAL MODIFICATION NSM-9 2025-05-13 Germany Acceptable
2024-10-30
2025-05-13