Double-blind, randomized, placebo-controlled, pilot clinical trial to evaluate the safety, tolerability and efficacy of two doses of a conditioned medium from a co-culture of M2-macrophages and fat-derived mesenchymal cells (PRS CK STORM) in the modulation of the cytokine storm in patients with acute respiratory infection caused by SARS-Cov-2, influenza A, influenza B and respiratory syncytial virus (RSV)

2023-507700-32-00 Protocol PRSCK-21P01 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 2 Oct 2024 · Status Ongoing, recruiting · 1 EU/EEA countries · 3 sites · Protocol PRSCK-21P01

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 50
Countries 1
Sites 3

Acute respiratory distress syndrome (ARDS) caused by SARS-Cov-2, influenza A, influenza B and respiratory syncytial virus (RSV)

Key facts

Sponsor
Peaches Biotech S.L.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Virus Diseases [C02]
Trial duration
2 Oct 2024 → ongoing
Decision date (initial)
2024-01-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Acute respiratory distress syndrome (ARDS) caused by SARS-Cov-2, influenza A, influenza B and respiratory syncytial virus (RSV)

VersionLevelCodeTermSystem organ class
21.1 PT 10001052 Acute respiratory distress syndrome 100000004855

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Peaches Biotech S.L.

Sponsor organisation
Peaches Biotech S.L.
Address
Calle De Isabel Colbrand 6
City
Madrid
Postcode
28050
Country
Spain

Scientific contact point

Organisation
Peaches Biotech S.L.
Contact name
Francesca Sarno

Public contact point

Organisation
Peaches Biotech S.L.
Contact name
Francesca Sarno

Locations

1 EU/EEA country · 3 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Ongoing, recruiting 50 3
Rest of world 0

Investigational sites

Spain

3 sites · Ongoing, recruiting
Hospital Universitario Reina Sofia
Servicio Enfermedades Infecciosas, Avenida Menendez Pidal S/n, 14004, Cordoba
Hospital Universitario Principe De Asturias
Medicina Interna, Carretera Meco S/n, 28805, Alcala De Henares
Hospital Universitario De Fuenlabrada
Medicina Interna, Camino Del Molino 2, 28942, Fuenlabrada

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Spain 2024-10-02 2024-11-13

Application history

7 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-10-12 Spain Acceptable with conditions
2024-01-22
2024-01-22
2 SUBSTANTIAL MODIFICATION SM-1 2024-07-26 Spain Acceptable
2024-09-11
2024-09-11
3 NON SUBSTANTIAL MODIFICATION NSM-1 2024-10-14 Spain Acceptable
2024-09-11
2024-10-14
4 SUBSTANTIAL MODIFICATION SM-2 2025-05-07 Spain Acceptable
2025-06-23
2025-06-23
5 NON SUBSTANTIAL MODIFICATION NSM-2 2025-08-06 Spain Acceptable
2025-06-23
2025-08-06
6 SUBSTANTIAL MODIFICATION SM-3 2025-11-24 Spain Acceptable 2026-01-15
7 SUBSTANTIAL MODIFICATION SM-4 2026-02-20 Spain Acceptable with conditions
2026-05-11
2026-05-13