A Study to assess the safety and potential use of GEH121224 (18F) Injection to visualise HER2-Receptor expression using PET imaging in patients with Metastatic Breast Cancer

2023-507720-23-00 Protocol GE-226-006 Phase I and Phase II (Integrated) - Other Ended

Start 15 Nov 2024 · End 3 Oct 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol GE-226-006

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - Other
Status Ended
Participants planned 43
Countries 1
Sites 1

Metastatic breast cancer

Key facts

Sponsor
GE Healthcare Limited
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Female
Therapeutic area
Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Investigative Techniques [E05]
Trial duration
15 Nov 2024 → 3 Oct 2025
Decision date (initial)
2024-10-01
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Metastatic breast cancer

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

GE Healthcare Limited

Sponsor organisation
GE Healthcare Limited
Address
Pollards Wood, Nightingales Lane Nightingales Lane
City
Chalfont St. Giles
Postcode
HP8 4SP
Country
United Kingdom

Scientific contact point

Organisation
GE Healthcare Limited
Contact name
Yaron Raiter, MD

Public contact point

Organisation
GE Healthcare Limited
Contact name
Yaron Raiter, MD

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Sweden Ended 43 1
Rest of world 0

Investigational sites

Sweden

1 site · Ended
Karolinska University Hospital
Nuclear Medicine, Halsovagen, Flemingsberg, Huddinge

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Sweden 2024-11-15 2025-01-24 2025-10-03

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-28 Sweden Acceptable
2024-09-30
2024-10-01
2 NON SUBSTANTIAL MODIFICATION NSM-1 2024-12-03 Sweden Acceptable
2024-09-30
2024-12-03
3 NON SUBSTANTIAL MODIFICATION NSM-2 2025-02-27 Sweden Acceptable
2024-09-30
2025-02-27
4 SUBSTANTIAL MODIFICATION SM-1 2025-05-15 Sweden Acceptable
2025-06-27
2025-06-27