A randomized, Phase 1b, single-center, observer-blind, active-controlled study to evaluate the safety, immunogenicity, and immunological mechanisms of one single administration of TETRALITE influenza vaccine at two dose levels of LiteVax Adjuvant, in healthy participants aged 60 years and older and in healthy participants aged 18 to 50 years.

2023-508230-33-00 Protocol TETRALITE-Ib Human pharmacology (Phase I) - Other Ended

Start 12 Jan 2024 · End 10 Oct 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol TETRALITE-Ib

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 70
Countries 1
Sites 1

Influenza

Key facts

Sponsor
LiteVax B.V.
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Virus Diseases [C02]
Trial duration
12 Jan 2024 → 10 Oct 2024
Decision date (initial)
2023-12-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Influenza

VersionLevelCodeTermSystem organ class
20.0 PT 10022000 Influenza 100000004862

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

LiteVax B.V.

Sponsor organisation
LiteVax B.V.
Address
Akkersestraat 50
City
Ophemert
Postcode
4061 BJ
Country
Netherlands

Scientific contact point

Organisation
LiteVax B.V.
Contact name
Luuk Hilgers

Public contact point

Organisation
LiteVax B.V.
Contact name
Luuk Hilgers

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ended 70 1
Rest of world 0

Investigational sites

Belgium

1 site · Ended
Universitair Ziekenhuis Gent
Center for Vaccinology (CEVAC), Corneel Heymanslaan 10, 9000, Gent

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2024-01-12 2024-10-10 2024-01-22 2024-04-05

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-10-12 Belgium Acceptable
2023-12-22
2023-12-22