A Phase 1 Study of BMS-986406 as Monotherapy and in Combination in Advanced Tumors

2023-508280-69-00 Protocol CA111-001 Human pharmacology (Phase I) - First administration to humans Ended

Start 7 Oct 2022 · End 17 Aug 2024 · Status Ended · 2 EU/EEA countries · 12 sites · Protocol CA111-001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ended
Participants planned 112
Countries 2
Sites 12

Advanced Malignant Tumors

Key facts

Sponsor
Bristol Myers Squibb International Corporation, Bristol Myers Squibb International Corporation
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
7 Oct 2022 → 17 Aug 2024
Decision date (initial)
2024-01-18
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2023-508280-69-00
EudraCT number
2021-006872-17
WHO UTN
U1111-1270-3670

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced Malignant Tumors

VersionLevelCodeTermSystem organ class
21.0 LLT 10048683 Advanced cancer 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bristol Myers Squibb International Corporation

Sponsor organisation
Bristol Myers Squibb International Corporation
Address
Terhulpsesteenweg 185
City
Watermaal-Bosvoorde
Postcode
1170
Country
Belgium

Scientific contact point

Organisation
Bristol Myers Squibb International Corporation
Contact name
Head of the GSM-CT

Public contact point

Organisation
Bristol Myers Squibb International Corporation
Contact name
Head of the GSM-CT

Bristol Myers Squibb International Corporation

Sponsor organisation
Bristol Myers Squibb International Corporation
Address
Terhulpsesteenweg 185
City
Watermaal-Bosvoorde
Postcode
1170
Country
Belgium

Locations

2 EU/EEA countries · 12 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ended 12 3
Spain Ended 15 9
Rest of world
United States, Korea, Republic of, Japan, Argentina
85

Investigational sites

Belgium

3 sites · Ended
UZ Brussel
Medical Oncology, Laarbeeklaan 101, 1090, Jette
Cliniques Universitaires Saint-Luc
Medical Oncology, Hippokrateslaan 10, Batiment 54, Sint-Lambrechts-Woluwe
Antwerp University Hospital
Oncology, Drie Eikenstraat 655, 2650, Edegem

Spain

9 sites · Ended
Institut Catala D'oncologia
Medical Oncology, Avinguda De La Gran Via De L'hospitalet 199-203, 08908, L'hospitalet De Llobregat
Clinica Universidad De Navarra
Medical Oncology, Avenue Pio XII 36, 31008, Pamplona
Hospital Universitari Vall D Hebron
Medical Oncology, Edificio Materno-Infantil, Passeig De La Vall D'hebron 119-129, Barcelona
Hospital Universitario Virgen De La Victoria
Medical Oncology, Calle Del Arroyo Teatinos Sn, 29010, Malaga
Hospital Hm Nou Delfos
Medical Oncology, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Universitario Hm Sanchinarro
Medical Oncology, Calle Ona 10, 28050, Madrid
Hospital Quironsalud Barcelona
Medical Oncology, Placa D'alfonso Comin 5-7, 08023, Barcelona
Clinica Universidad De Navarra
Medical Oncology, Calle Marquesado De Santa Marta 1, 28027, Madrid
Hospital Universitario 12 De Octubre
Medical Oncology, Bloque D, Avenida De Cordoba Sn, Madrid

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2022-12-22 2022-12-22 2023-12-31
Spain 2022-10-07 2022-10-07 2023-12-31

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-12-08 Belgium Acceptable
2024-01-08
2024-01-09
2 NON SUBSTANTIAL MODIFICATION NSM-1 2024-01-15 Belgium Acceptable
2024-01-08
2024-01-15
3 NON SUBSTANTIAL MODIFICATION NSM-3 2024-03-14 Belgium Acceptable
2024-01-08
2024-03-14
4 NON SUBSTANTIAL MODIFICATION NSM-4 2024-03-29 Belgium Acceptable
2024-01-08
2024-03-29
5 NON SUBSTANTIAL MODIFICATION NSM-5 2024-04-25 Belgium Acceptable
2024-01-08
2024-04-25