A Randomized, Multiple-Dose, Open-Label, Parallel-Group Study to Evaluate the Pharmacokinetic Profiles of LY03010 and the Relative Bioavailability at Steady-State of LY03010 versus XEPLION® in Patients with Schizophrenia

2023-508981-13-00 Protocol LY03010/CT-EUR-102 Human pharmacology (Phase I) - Bioequivalence study Authorised, recruitment pending

Status Authorised, recruitment pending · 4 EU/EEA countries · 19 sites · Protocol LY03010/CT-EUR-102

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Authorised, recruitment pending
Participants planned 328
Countries 4
Sites 19

Schizophrenia

Key facts

Sponsor
Geneora Pharma (Shijiazhuang) Co. Ltd.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Psychiatry and Psychology [F] - Mental Disorders [F03]
Decision date (initial)
2024-04-08
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Schizophrenia

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Geneora Pharma (Shijiazhuang) Co. Ltd.

Sponsor organisation
Geneora Pharma (Shijiazhuang) Co. Ltd.
Address
Runjiang Headquarters International Building 5th Floor, No. 455 Yuhua East Rd, High-Tech Zone No. 455 Yuhua East Rd High-Tech Zone
City
Shijiazhuang
Postcode
050031
Country
China

Scientific contact point

Organisation
Geneora Pharma (Shijiazhuang) Co. Ltd.
Contact name
Maggie Wang

Public contact point

Organisation
Geneora Pharma (Shijiazhuang) Co. Ltd.
Contact name
Maggie Wang

Locations

4 EU/EEA countries · 19 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Authorised, recruitment pending 85 11
Croatia Authorised, recruitment pending 29 3
Italy 0 1
Portugal Authorised, recruitment pending 56 4
Rest of world
Bosnia and Herzegovina, Serbia, Georgia, Turkey, Moldova, Republic of
158

Investigational sites

Bulgaria

11 sites · Authorised, recruitment pending
Center For Mental Health Vratsa EOOD
psychiatry, Belasita Str 1, 3000, Vratsa
Multiprofile Hospital For Active Treatment - Targovishte AD
psychiatry, West District, Syuren Blvd 1, Targovishte
Center For Skin And Venereal Diseases Veliko Tarnovo EOOD
psychiatry, Ulitsa Buzludzha 1, 5000, Veliko Tirnovo
University Multiprofile Hospital For Active Treatment Dr. Georgi Stranski EAD
psychiatry, Ulitsa Georgi Kochev 8-A, 5803, Pleven
"Multiprofile Hospital for Active Treatment Dr. Hristo Stambolski"
psychiatry, 16 "Starozagorska" Str.;, 6100, Kazanlak
State Psychiatric Hospital Tsarev Brod
psychiatry, Village, Hristo Botev St 30, Tsarev Brod
Diagnostics-Consultancy Center Mladost M Varna OOD
psychiatry, Bulevard Republika 15, 9020, Varna
Alexandrovska University Hospital
psychiatry, Georgy Sofiiski Str 1, 1431, Sofia
MBAL Dr. Ivan Seliminski - Sliven AD
psychiatry, Bulevard Hristo Botev 1, 8801, Sliven
Outpatient Clinic For Specialized Medical Care-Individual Practice For Specialized Medical Care-Psychiatry Dr. Georgi Hranov
psychiatry, Tzurnook Str 8, 1421, Sofia
Higya–DCC OOD
psychiatry, Ulitsa Sveti Ivan Rilski 3, 4400, Pazardzhik

Croatia

3 sites · Authorised, recruitment pending
KBC Split
psychiatry, Soltanska 1, 21000, Split
Klinika za psihijatriju Vrapce
psychiatry, Bolnicka Cesta 32, Zagreb, Grad Zagreb
Clinic for psychiatry Sveti Ivan
psychiatry, Jankomir 11, Zagreb, Grad Zagreb

Italy

1 site ·
Mental Health Center Prof. Dr. Ivan Temkov
psychiatry, Complex Lazur, Park Ezero, Bourgas

Portugal

4 sites · Authorised, recruitment pending
Hospitais Senhor Do Bonfim S.A.
Neurosciences, Rua Da Mata 180, Vila Do Conde, Touguinho
Centro Hospitalar De Vila Nova De Gaia/Espinho E.P.E.
Psychiatry and Mental Health Service, Rua Conceicao Fernandes S/n, 4434-502, Vila Nova De Gaia
CCAB Centro Clinico Academico Braga Associacao
Psychiatry Service, Lugar De Sete Fontes S Victor, 4710-243, Braga
Centro Hospitalar De Leiria E.P.E.
Psychiatry, Rua Das Olhalvas, 2410-197, Leiria

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-11-24 Portugal Acceptable
2024-04-01
2024-04-04
2 SUBSTANTIAL MODIFICATION SM-1 2024-06-04 Acceptable 2024-08-27