A study to investigate the safety and tolerability of dostarlimab in adult participants with chronic HBV infection on nucleos(t)ide analogue (NA) treatment

2023-509027-41-00 Protocol 222110 Human pharmacology (Phase I) - Other Ended

End 3 Dec 2024 · Status Ended · 4 EU/EEA countries · 11 sites · Protocol 222110

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 32
Countries 4
Sites 11

Hepatitis B, Chronic

Key facts

Sponsor
Glaxosmithkline Research & Development Limited
Participant type
Patients
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Virus Diseases [C02]
Trial duration
completed 3 Dec 2024
Decision date (initial)
2024-11-15
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Hepatitis B, Chronic

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Glaxosmithkline Research & Development Limited

Sponsor organisation
Glaxosmithkline Research & Development Limited
Address
G S K House, 980 Great West Road 980 Great West Road
City
Brentford
Postcode
TW8 9GS
Country
United Kingdom

Scientific contact point

Organisation
Glaxosmithkline Research & Development Limited
Contact name
EU GSK Clinical Trials Call Center

Public contact point

Organisation
Glaxosmithkline Research & Development Limited
Contact name
EU GSK Clinical Trials Call Center

Locations

4 EU/EEA countries · 11 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Ended 6 2
France Ended 5 3
Italy Ended 5 3
Spain Ended 7 3
Rest of world
Thailand, United States
9

Investigational sites

Bulgaria

2 sites · Ended
Diagnostic-Consultative Center Alexandrovska EOOD
N/A, Triaditsa, Ulitsa Sveti Georgi Sofiyski 1, Sofiya
Diagnostics-Consultancy Center Mladost M Varna OOD
N/A, Bulevard Republika 15, 9020, Varna

France

3 sites · Ended
Hopital Beaujon
Service d'Hépatologie, 100 Boulevard Du General Leclerc, 92110, Clichy
Les Hopitaux Universitaires De Strasbourg
Nouvel Hopital Civil - Medical unit of Hepato-gastroenterology and endoscopy, 1 Place De L Hopital, Cs 80426, Strasbourg Cedex
Hospices Civils De Lyon
Hopital de la Croix Rousse - Hepatogastroenterology, 103 Grande Rue De La Croix Rousse, 69317, Lyon Cedex 04

Italy

3 sites · Ended
Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii
SC Gastroenterologia 1, Epatologia e Trapiantologia, Piazza Oms 1, 24127, Bergamo
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
SC Gastroenterologia ed Epatologia, Via Francesco Sforza 28, 20122, Milan
Fondazione IRCCS San Gerardo Dei Tintori
Centro Ricerca di Fase I, Via Giovanni Battista Pergolesi 33, 20900, Monza

Spain

3 sites · Ended
Hospital Universitario Marques De Valdecilla
Digestive system service, Avenida Valdecilla Sn, 39008, Santander
University Hospital Virgen Del Rocio S.L.
Digestive system service, Avenida De Manuel Siurot S/n, 41013, Sevilla
University Hospital Son Espases
Digestive service, Carretera Valldemossa 79, 07120, Palma

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-07-26 Spain Acceptable
2024-11-11
2024-11-11