First in human study in healthy volunteers and participants with Parkinsons disease with and without GBA1 mutations.

2023-509158-68-00 Protocol VQ101-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 25 Jan 2024 · Status Ongoing, recruiting · 1 EU/EEA countries · 2 sites · Protocol VQ101-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 200
Countries 1
Sites 2

Parkinson’s disease

Key facts

Sponsor
Vanqua Bio Inc.
Participant type
Patients, Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nervous System Diseases [C10]
Trial duration
25 Jan 2024 → ongoing
Decision date (initial)
2024-01-25
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Parkinson’s disease

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Vanqua Bio Inc.

Sponsor organisation
Vanqua Bio Inc.
Address
1375 West Fulton Street Suite 600
City
Chicago
Postcode
60607-1157
Country
United States

Scientific contact point

Organisation
Vanqua Bio Inc.
Contact name
Brieana Sommer

Public contact point

Organisation
Vanqua Bio Inc.
Contact name
Brieana Sommer

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ongoing, recruiting 200 2
Rest of world 0

Investigational sites

Netherlands

2 sites · Ongoing, recruiting
Centre for Human Drug Research
Neurology, Zernikedreef 8, 2333 CL, Leiden
Pharmaceutical Research Associates Group B.V.
General, Van Swietenlaan 6, 9728 NZ, Groningen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2024-01-25 2024-01-31

Application history

13 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-11-27 Netherlands Acceptable
2024-01-25
2024-01-25
2 NON SUBSTANTIAL MODIFICATION NSM-1 2024-03-21 Netherlands Acceptable
2024-01-25
2024-03-21
3 SUBSTANTIAL MODIFICATION SM-1 2024-03-22 Netherlands Acceptable
2024-04-03
2024-04-03
4 SUBSTANTIAL MODIFICATION SM-2 2024-04-17 Netherlands Acceptable
2024-05-01
2024-05-01
5 NON SUBSTANTIAL MODIFICATION NSM-2 2024-05-03 Netherlands Acceptable
2024-05-01
2024-05-03
6 SUBSTANTIAL MODIFICATION SM-3 2024-09-06 Netherlands Acceptable
2024-10-04
2024-10-04
7 SUBSTANTIAL MODIFICATION SM-4 2024-10-08 Netherlands Acceptable
2024-10-24
2024-10-24
8 SUBSTANTIAL MODIFICATION SM-5 2024-12-06 Netherlands Acceptable
2024-12-16
2024-12-16
9 SUBSTANTIAL MODIFICATION SM-6 2025-01-23 Netherlands Acceptable
2025-02-04
2025-02-04
10 SUBSTANTIAL MODIFICATION SM-7 2025-03-18 Netherlands Acceptable
2025-03-27
2025-03-28
11 NON SUBSTANTIAL MODIFICATION NSM-3 2025-04-24 Netherlands Acceptable
2025-03-27
2025-04-24
12 SUBSTANTIAL MODIFICATION SM-8 2025-06-27 Netherlands Acceptable
2025-07-14
2025-07-14
13 SUBSTANTIAL MODIFICATION SM-9 2025-08-22 Netherlands Acceptable
2025-09-24
2025-09-24