First-in human, dose escalation and cohort expansion study for the evaluation of LB-208 (HTR1B antagonist) in adult patients with relapsed or refractory solid tumours and lymphoma

2023-509532-25-00 Protocol LB-208-001 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 7 Aug 2024 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol LB-208-001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 57
Countries 1
Sites 1

Solid tumor

Key facts

Sponsor
Leukos Biotech S.L.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
7 Aug 2024 → ongoing
Decision date (initial)
2024-06-11
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Solid tumor

VersionLevelCodeTermSystem organ class
20.0 HLGT 10025323 Lymphomas NEC 10029104
21.1 LLT 10065147 Malignant solid tumor 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Leukos Biotech S.L.

Sponsor organisation
Leukos Biotech S.L.
Address
Calle Muntaner 383
City
Barcelona
Postcode
08021
Country
Spain

Scientific contact point

Organisation
Leukos Biotech S.L.
Contact name
Ruth Muñoz Risueño

Public contact point

Organisation
Leukos Biotech S.L.
Contact name
Luís Ruiz-Avila

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Ongoing, recruiting 57 1
Rest of world 0

Investigational sites

Spain

1 site · Ongoing, recruiting
Hospital Universitari Vall D Hebron
Oncology, Edificio Materno-Infantil, Passeig De La Vall D'hebron 119-129, Barcelona

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Spain 2024-08-07 2024-08-14

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-03-05 Spain Acceptable
2024-06-05
2024-06-11
2 SUBSTANTIAL MODIFICATION SM-1 2025-01-31 Spain Acceptable
2025-04-10
2025-04-10
3 SUBSTANTIAL MODIFICATION SM-2 2025-10-03 Spain Acceptable
2026-01-26
2026-02-02