A First In Human Phase I Trial Evaluating safety, tolErability and ResponSe of [211At]At-Girentuximab (ATO-101™) in PatiEnts with Non-Muscle-InVasive BladdER CANCEr Refractory to Standard Treatment (PERSEVERANCE EU)

2023-509729-33-00 Protocol PERSEVERANCE EU Human pharmacology (Phase I) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol PERSEVERANCE EU

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruitment pending
Participants planned 24
Countries 1
Sites 1

Non-Muscle-Invasive Bladder Cancer (NMIBC) refractory

Key facts

Sponsor
Institut De Cancerologie De L Ouest
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2025-11-26
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Non-Muscle-Invasive Bladder Cancer (NMIBC) refractory

VersionLevelCodeTermSystem organ class
25.0 LLT 10087211 Non-muscle invasive bladder cancer 100000004848

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Institut De Cancerologie De L Ouest

Sponsor organisation
Institut De Cancerologie De L Ouest
Address
Bd Du Professeur Jacques Monod
City
St Herblain
Postcode
44800
Country
France

Scientific contact point

Organisation
Institut De Cancerologie De L Ouest
Contact name
Caroline ROUSSEAU

Public contact point

Organisation
Institut De Cancerologie De L Ouest
Contact name
Nadia ALLAM

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 24 1
Rest of world 0

Investigational sites

France

1 site · Authorised, recruitment pending
Institut De Cancerologie De L Ouest
Nuclear Medicine, Boulevard Jacques Monod, 44805, Saint-Herblain Cedex

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-08-18 France Acceptable with conditions
2025-11-26
2025-11-26