A Phase 1 Trial Investigating LY4101174, an Antibody-Drug Conjugate Targeting Nectin-4, in Participants with Recurrent, Advanced or Metastatic Solid Tumors

2023-509867-26-00 Protocol LOXO-ENC-23001 Human pharmacology (Phase I) - First administration to humans Ongoing, recruitment ended

Start 14 Oct 2024 · Status Ongoing, recruitment ended · 3 EU/EEA countries · 10 sites · Protocol LOXO-ENC-23001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruitment ended
Participants planned 466
Countries 3
Sites 10

Advanced/metastatic solid tumor

Key facts

Sponsor
Eli Lilly & Co.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
14 Oct 2024 → ongoing
Decision date (initial)
2024-05-23
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2023-509867-26-00
WHO UTN
U1111-1300-2546

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced/metastatic solid tumor

VersionLevelCodeTermSystem organ class
21.1 LLT 10065252 Solid tumor 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Eli Lilly & Co.

Sponsor organisation
Eli Lilly & Co.
Address
1 Lilly Corporate Center
City
Indianapolis
Postcode
46285-0001
Country
United States

Scientific contact point

Organisation
Eli Lilly & Co.
Contact name
Eli Lilly & Co.

Public contact point

Organisation
Eli Lilly & Co.
Contact name
Eli Lilly & Co.

Locations

3 EU/EEA countries · 10 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ongoing, recruitment ended 23 1
France Ongoing, recruitment ended 50 5
Spain Ongoing, recruitment ended 53 4
Rest of world
Japan, China, Australia, United States
340

Investigational sites

Belgium

1 site · Ongoing, recruitment ended
Institut Jules Bordet
001:Oncologie Médicale, Mijlenmeersstraat 90, 1070, Anderlecht

France

5 sites · Ongoing, recruitment ended
Institut Gustave Roussy
104: Département d'innovation Thérapeutique et Essais Précoces (DITEP), 114 Rue Edouard Vaillant, 94800, Villejuif
Centre Leon Berard
101: département d'oncologie médica, 28 Rue Laennec, 69008, Lyon
Les Hopitaux Universitaires De Strasbourg
106: Medical Oncology, 1 Avenue Moliere, Bp 49, Strasbourg Cedex 2
Centre Oscar Lambret
105: Cancérologie Générale, 3 Rue Frederic Combemale, 59000, Lille
Institut Paoli-Calmettes
102: Oncologie Medicale - Cancerolo, 232 Boulevard De Sainte Marguerite, Bp 156, Marseille

Spain

4 sites · Ongoing, recruitment ended
MD Anderson Cancer Center
201: Oncología, Calle De Arturo Soria Nº 270, 28033, Madrid
Hospital Universitari Vall D Hebron
204:Oncología Médica, Passeig De La Vall D'Hebron 119-129, 08035, Barcelona
Hospital Universitario 12 De Octubre
202:Oncología Médica, Bloque D, Avenida De Cordoba Sn, Madrid
University Hospital Virgen Del Rocio S.L.
203:Oncología, Avenida De Manuel Siurot S/n, 41013, Sevilla

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2024-10-25 2024-10-29 2026-03-03
France 2024-12-16 2024-12-27 2026-03-03
Spain 2024-10-14 2024-10-29 2026-03-03

Application history

7 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-01-31 France Acceptable with conditions
2024-05-21
2024-05-22
2 SUBSTANTIAL MODIFICATION SM-1 2024-06-11 France Acceptable
2024-08-29
2024-08-30
3 SUBSTANTIAL MODIFICATION SM-2 2025-01-13 France Acceptable
2025-03-25
2025-03-25
4 SUBSTANTIAL MODIFICATION SM-3 2025-04-01 Acceptable 2025-04-09
5 SUBSTANTIAL MODIFICATION SM-4 2025-06-24 France Acceptable
2025-08-29
2025-08-29
6 SUBSTANTIAL MODIFICATION SM-5 2025-10-10 Acceptable 2025-10-23
7 SUBSTANTIAL MODIFICATION SM-6 2025-10-24 France Acceptable 2025-11-13