A study to investigate the safety and pharmacological effect of a single intravenous infusion of GSK2857914 in male and female participants aged 18 to 75 with moderate to severe systemic lupus erythematosus

2023-510340-20-00 Protocol 221615 Human pharmacology (Phase I) - Other Ended

End 6 May 2025 · Status Ended · 2 EU/EEA countries · 5 sites · Protocol 221615

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 19
Countries 2
Sites 5

Systemic Lupus Erythematosus

Key facts

Sponsor
Glaxosmithkline Research & Development Limited
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Immune System Diseases [C20]
Trial duration
completed 6 May 2025
Decision date (initial)
2025-02-26
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2023-510340-20-00
ClinicalTrials.gov
NCT06413511

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Systemic Lupus Erythematosus

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Glaxosmithkline Research & Development Limited

Sponsor organisation
Glaxosmithkline Research & Development Limited
Address
G S K House, 980 Great West Road 980 Great West Road
City
Brentford
Postcode
TW8 9GS
Country
United Kingdom

Scientific contact point

Organisation
Glaxosmithkline Research & Development Limited
Contact name
EU GSK Clinical Trials Call Center

Public contact point

Organisation
Glaxosmithkline Research & Development Limited
Contact name
EU GSK Clinical Trials Call Center

Locations

2 EU/EEA countries · 5 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ended 3 3
Spain Ended 3 2
Rest of world
United States
13

Investigational sites

France

3 sites · Ended
Assistance Publique Hopitaux De Paris
Hospital Pitie Salpetriere Service de Medecine maladies auto-immunes et systemique, 47 Boulevard De L Hopital, 75651, Paris Cedex 13
Centre Hospitalier Universitaire De Bordeaux
Hospital Saint Andre Service de medecine interne et immunologie clinique, 1 Rue Jean Burguet, 33000, Bordeaux
Centre Hospitalier Universitaire De Toulouse
Hospital Rangueil Service de medecine interne et immunologie clinique, 1 Avenue Du Professeur Jean Poulhes, Tsa 50032, Toulouse Cedex 9

Spain

2 sites · Ended
Hospital Clinico San Carlos
Servicio de Farmacología Clínica, Calle Del Profesor Martín Lagos S/n, 28040, Madrid
Hospital Universitario La Paz
Servicio de Medicina Interna, Paseo De La Castellana 261, 28046, Madrid

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-07-24 Spain Acceptable
2024-10-28
2024-10-28
2 SUBSEQUENT ADDITION OF MSC APP-2 2024-11-26 Acceptable
2024-10-28
2025-02-26