A Single-Center, Open-Label, Two-Period Study to Investigate the Effect of Multiple Dose Itraconazole, a Strong CYP3A Inhibitor, on the Pharmacokinetics of a Single 30 MG Dose of RO7269162 in Healthy Participants

2024-510732-52-00 Protocol BP45228 Human pharmacology (Phase I) - Other Ended

Start 7 May 2024 · End 2 Aug 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol BP45228

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 18
Countries 1
Sites 1

Not applicable, healthy volunteers

Key facts

Sponsor
F. Hoffmann-La Roche AG
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
7 May 2024 → 2 Aug 2024
Decision date (initial)
2024-05-01
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Not applicable, healthy volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

F. Hoffmann-La Roche AG

Sponsor organisation
F. Hoffmann-La Roche AG
Address
Grenzacherstrasse 124
City
Basel
Postcode
4058
Country
Switzerland

Scientific contact point

Organisation
F. Hoffmann-La Roche AG
Contact name
Trial Information System -TISL

Public contact point

Organisation
F. Hoffmann-La Roche AG
Contact name
Trial Information System -TISL

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ended 18 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ended
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2024-05-07 2024-08-01 2024-06-06 2024-06-13

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-03-25 Netherlands Acceptable
2024-05-01
2024-05-01