A study to test whether BI 456906 (survodutide) influences the amount of bupropion, caffeine and midazolam in the blood in people with overweight or obesity

2024-512332-29-00 Protocol 1404-0008 Human pharmacology (Phase I) - Other Ended

Start 5 Sep 2024 · End 5 Jan 2026 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol 1404-0008

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 30
Countries 1
Sites 1

Overweight

Key facts

Sponsor
Boehringer Ingelheim International GmbH
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nutritional and Metabolic Diseases [C18]
Trial duration
5 Sep 2024 → 5 Jan 2026
Decision date (initial)
2024-08-05
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-512332-29-00
WHO UTN
U1111-1307-0132

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Overweight

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Boehringer Ingelheim International GmbH

Sponsor organisation
Boehringer Ingelheim International GmbH
Address
Binger Strasse 173
City
Ingelheim Am Rhein
Postcode
55216
Country
Germany

Scientific contact point

Organisation
Boehringer Ingelheim International GmbH
Contact name
CT Disclosure & Data Transparency

Public contact point

Organisation
Boehringer Ingelheim International GmbH
Contact name
CT Disclosure & Data Transparency

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ended 30 1
Rest of world 0

Investigational sites

Belgium

1 site · Ended
SGS Belgium
Clinical Pharmacology Unit, Drie Eikenstraat 655, 2650, Edegem

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2024-09-05 2026-01-05 2024-10-03 2025-04-25

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-26 Belgium Acceptable
2024-08-05
2024-08-05
2 SUBSTANTIAL MODIFICATION SM-1 2025-02-13 Belgium Acceptable
2025-02-27
2025-03-04
3 SUBSTANTIAL MODIFICATION SM-2 2025-04-03 Belgium Acceptable
2025-04-15
2025-04-15
4 SUBSTANTIAL MODIFICATION SM-3 2025-10-07 Belgium Acceptable 2025-10-23