Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma

2024-513619-28-00 Protocol XmAb819-01 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 11 Dec 2025 · Status Ongoing, recruiting · 3 EU/EEA countries · 17 sites · Protocol XmAb819-01

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 190
Countries 3
Sites 17

Clear Cell Renal Cell Carcinoma

Key facts

Sponsor
Xencor Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
11 Dec 2025 → ongoing
Decision date (initial)
2024-12-18
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2024-513619-28-00
ClinicalTrials.gov
NCT05433142

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Clear Cell Renal Cell Carcinoma

VersionLevelCodeTermSystem organ class
21.0 PT 10073251 Clear cell renal cell carcinoma 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Xencor Inc.

Sponsor organisation
Xencor Inc.
Address
465 North Halstead Street Suite 200
City
Pasadena
Postcode
91107-3291
Country
United States

Scientific contact point

Organisation
Xencor Inc.
Contact name
Chet Bohac, MD

Public contact point

Organisation
Xencor Inc.
Contact name
Chet Bohac, MD

Locations

3 EU/EEA countries · 17 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ongoing, recruiting 16 4
France Ongoing, recruiting 16 4
Spain Ongoing, recruiting 16 9
Rest of world
United States, United Kingdom
142

Investigational sites

Belgium

4 sites · Ongoing, recruiting
UZ Leuven
Oncology, Herestraat 49, 3000, Leuven
Antwerp University Hospital
Oncology, Drie Eikenstraat 655, 2650, Edegem
Az Maria Middelares Gent
Oncology, Buitenring-Sint-Denijs 30, 9000, Gent
Cliniques Universitaires Saint-Luc
Oncology, Hippokrateslaan 10, Batiment 54, Sint-Lambrechts-Woluwe

France

4 sites · Ongoing, recruiting
Institut Gustave Roussy
Medical Oncology, 114 Rue Edouard Vaillant, 94800, Villejuif
Centre Hospitalier Universitaire De Bordeaux
Medical Oncology, 1 Rue Jean Burguet, 33000, Bordeaux
Institut Paoli Calmettes
Medical Oncology, 232 Boulevard De Sainte Marguerite, Bp 156, Marseille
Institut De Cancerologie De L Ouest
Medical Oncology, Boulevard Jacques Monod, 44805, Saint-Herblain Cedex

Spain

9 sites · Ongoing, recruiting
Hospital Del Mar
Oncology Service, Passeig Maritim De La Barceloneta 25-29, 08003, Barcelona
Hospital Universitario Hm Sanchinarro
Oncology Service, Calle Ona 10, 28050, Madrid
Clinica Universidad De Navarra
Oncology Service, Pio XII Etorbidea 36, 31008, Pamplona
Parc Tauli Hospital Universitari
Oncology Service, Parc Del Tauli 1, 08208, Sabadell
Clinica Universidad De Navarra
Oncology Service, Calle Marquesado De Santa Marta 1, 28027, Madrid
Hospital Universitario 12 De Octubre
Oncology Service, Avenida De Cordoba Sn, 28041, Madrid
University Hospital Virgen Del Rocio S.L.
Oncology Service, Avenida De Manuel Siurot S/n, 41013, Sevilla
Hospital De La Santa Creu I Sant Pau
Oncology Service, Calle De San Antonio Maria Claret 167, 08025, Barcelona
Hospital Universitari Vall D Hebron
Oncology Service, Passeig De La Vall D'Hebron 119-129, 08035, Barcelona

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2026-01-15 2026-05-04
France 2025-12-11 2026-01-23
Spain 2026-01-19 2026-02-03

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-08-26 France Acceptable with conditions
2024-12-16
2024-12-18
2 SUBSTANTIAL MODIFICATION SM-1 2025-06-13 France Acceptable
2025-09-19
2025-09-22