Phase I clinical trial of TG4050 combined with nivolumab in patients with Non-Small Cell Lung Cancer.

2024-514001-65-00 Protocol TG4050.03 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol TG4050.03

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 40
Countries 1
Sites 1

Non-Small Cell Lung Cancer

Key facts

Sponsor
Transgene
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2024-10-03
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Non-Small Cell Lung Cancer

VersionLevelCodeTermSystem organ class
21.1 PT 10029519 Non-small cell lung cancer stage III 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Transgene

Sponsor organisation
Transgene
Address
Parc D Innovation, 400 Boulevard Gonthier D Andernach, Cs 80166 Illkirch Graffenstaden, Illkirch Graffenstaden 400 Boulevard Gonthier D Andernach Cs 80166 Illkirch Graffenstaden
City
Illkirch Cedex
Postcode
67405
Country
France

Scientific contact point

Organisation
Transgene
Contact name
Transgene medical affairs

Public contact point

Organisation
Transgene
Contact name
Transgene medical affairs

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 20 1
Rest of world
United Kingdom
20

Investigational sites

France

1 site · Authorised, recruitment pending
Institut Curie
Departement oncologie medicale, 26 Rue D Ulm, 75005, Paris

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-28 France Acceptable
2024-10-03
2024-10-03
2 SUBSTANTIAL MODIFICATION SM-1 2024-12-22 France Acceptable
2025-03-24
2025-03-28