An open-label, crossover trial in otherwise healthy volunteers with allergic rhinitis to evaluate the relative bioavailability and hemodynamic effects of OX640 nasal epinephrine powder to a marketed epinephrine intramuscular injection

2024-514037-38-00 Protocol OX640-002 Human pharmacology (Phase I) - Other Ended

Start 1 Oct 2024 · End 12 Dec 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol OX640-002

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 30
Countries 1
Sites 1

Anaphylaxis

Key facts

Sponsor
Orexo AB
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
1 Oct 2024 → 12 Dec 2024
Decision date (initial)
2024-09-11
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Anaphylaxis

VersionLevelCodeTermSystem organ class
23.1 LLT 10002218 Anaphylaxis 10021428

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Orexo AB

Sponsor organisation
Orexo AB
Address
Virdings Alle 32 A, Vaksala Vaksala
City
Uppsala
Postcode
754 50
Country
Sweden

Scientific contact point

Organisation
Orexo AB
Contact name
Martin Jönsson, Clinical Pharmacologist

Public contact point

Organisation
Orexo AB
Contact name
Martin Jönsson, Clinical Pharmacologist

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Sweden Ended 30 1
Rest of world 0

Investigational sites

Sweden

1 site · Ended
CTC Clinical Trial Consultants AB
CTC, Dag Hammarskjolds Vag 10b, Uppsala Domkyrkofors., Uppsala

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Sweden 2024-10-01 2024-12-12 2024-10-01 2024-11-21

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-28 Sweden Acceptable
2024-09-11
2024-09-11