Oncolytic virus TILT-123 in combination with lymphocyte-depleting chemotherapy and TILs in the treatment of melanoma

2024-514092-18-00 Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 31 Mar 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 9
Countries 1
Sites 1

Melanoma

Key facts

Sponsor
TILT Biotherapeutics Oy
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
31 Mar 2025 → ongoing
Decision date (initial)
2024-09-05
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Melanoma

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

TILT Biotherapeutics Oy

Sponsor organisation
TILT Biotherapeutics Oy
Address
Tukholmankatu 8b
City
Helsinki
Postcode
00290
Country
Finland

Scientific contact point

Organisation
TILT Biotherapeutics Oy
Contact name
Trial Team

Public contact point

Organisation
TILT Biotherapeutics Oy
Contact name
Trial Team

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Denmark Ongoing, recruiting 9 1
Rest of world 0

Investigational sites

Denmark

1 site · Ongoing, recruiting
Region Hovedstaden
Department of Oncology, Borgmester Ib Juuls Vej 1, 2730, Herlev

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Denmark 2025-03-31 2025-06-25

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-11 Denmark Acceptable
2024-09-02
2024-09-05
2 SUBSTANTIAL MODIFICATION SM-1 2024-12-17 Denmark Acceptable
2025-02-12
2025-02-13
3 SUBSTANTIAL MODIFICATION SM-2 2025-05-04 Denmark Acceptable
2025-06-02
2025-06-03
4 SUBSTANTIAL MODIFICATION SM-3 2025-10-20 Denmark Acceptable
2025-11-27
2025-11-27
5 SUBSTANTIAL MODIFICATION SM-4 2026-01-30 Denmark Acceptable
2026-02-20
2026-02-23