A Phase I, Randomised, Open Label, Single Center, Single Oral Dose, Three Treatment, Three Period, Three Sequence, Change-over Bioequivalence Study of Paracetamol Orodispersible Tablet 500 mg (Haleon) to assess Bioequivalence with Alvedon 500 mg Film-Coated Tablet (Haleon, Sweden) and Panadol 500 mg Film-Coated Tablet (Haleon, Australia) in Healthy Adult Subjects Under Fasting Conditions

2024-514198-23-00 Protocol 300141 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 5 Mar 2025 · End 16 Jun 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol 300141

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 54
Countries 1
Sites 1

Healthy volunteers, therapeutic indication not studied

Key facts

Sponsor
Haleon CH SARL
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
5 Mar 2025 → 16 Jun 2025
Decision date (initial)
2024-12-10
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy volunteers, therapeutic indication not studied

VersionLevelCodeTermSystem organ class
21.1 LLT 10016283 Febrile cold (excl flu like illness) 10021881
20.0 PT 10028391 Musculoskeletal pain 100000004859
20.0 LLT 10031304 Otalgia 10013993
20.1 LLT 10034532 Period pains 10038604
27.0 PT 10068879 Vaccination site pain 100000004867
20.0 LLT 10016558 Fever 10018065
23.1 LLT 10049749 Post procedural pain 10022117
22.0 PT 10019211 Headache 100000004852
20.0 LLT 10027602 Migraine headache 10029205
21.1 PT 10040747 Sinus pain 100000004855
21.1 LLT 10028287 Muscle ache 10028395
20.0 PT 10044055 Toothache 100000004856
20.0 PT 10031161 Osteoarthritis 100000004859
20.1 LLT 10065602 Fluctuating fever 10018065
27.0 LLT 10088364 Post vaccination fever 100000004863
20.0 LLT 10014037 Earache 10013993
20.0 LLT 10003993 Backache 10028395

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Haleon CH SARL

Sponsor organisation
Haleon CH SARL
Address
Case Postale 1279
City
Nyon 1
Postcode
1260
Country
Switzerland

Scientific contact point

Organisation
Haleon CH SARL
Contact name
Haleon Contact Point Clinical trials

Public contact point

Organisation
Haleon CH SARL
Contact name
Haleon Contact Point Clinical trials

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 54 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
SocraTec R&D Concepts in Drug Research and Development GmbH
Clinical Pharmacology Unit, Mainzerhofplatz 14, Erfurt-Altstadt, Erfurt

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2025-03-05 2025-06-16 2025-03-05 2025-04-17

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-10-25 Germany Acceptable
2024-11-29
2024-12-10
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-02-24 Germany Acceptable
2024-11-29
2025-02-24
3 NON SUBSTANTIAL MODIFICATION NSM-2 2025-06-04 Germany Acceptable
2024-11-29
2025-06-04