An open-label, prospective, randomised, cross-over trial to assess the pharmacokinetics of an amorphous formulation of sorafenib in mesoporous magnesium carbonate (DPH001) compared to Nexavar® (sorafenib) in healthy volunteers

2024-514496-18-00 Protocol DPH001-01 Human pharmacology (Phase I) - Other Not authorised

Status Not authorised · 1 EU/EEA countries · 1 sites · Protocol DPH001-01

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Not authorised
Participants planned 20
Countries 1
Sites 1

Hepatocellular carcinoma, renal cell carcinoma and differentiated thyroid carcinoma.

Key facts

Sponsor
Disruptive Pharma AB
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Not possible to specify
Decision date (initial)
2024-08-27
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Hepatocellular carcinoma, renal cell carcinoma and differentiated thyroid carcinoma.

VersionLevelCodeTermSystem organ class
20.0 PT 10073071 Hepatocellular carcinoma 100000004864
21.1 LLT 10007476 Carcinoma thyroid 10029104
21.1 PT 10067946 Renal cell carcinoma 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Disruptive Pharma AB

Sponsor organisation
Disruptive Pharma AB
Address
Uppsala Science Park
City
Uppsala
Postcode
751 83
Country
Sweden

Scientific contact point

Organisation
Disruptive Pharma AB
Contact name
Malin Vågerö, Director R&D

Public contact point

Organisation
Disruptive Pharma AB
Contact name
Peter Åsberg, CEO

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Sweden Not authorised 20 1
Rest of world 0

Investigational sites

Sweden

1 site · Not authorised
CTC Clinical Trial Consultants AB
CTC, Dag Hammarskjolds Vag 10b, Uppsala Domkyrkofors., Uppsala

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-07 Sweden Not acceptable
2024-08-27
2024-08-27