A Phase I, open-label, fixed sequence drug interaction study in healthy subjects to investigate the effect of a 40 mg deucrictibant tablet administered once daily on the pharmacokinetics of the P-gp substrate digoxin and the BCRP substrate rosuvastatin, administered as a drug cocktail

2024-514713-35-00 Protocol PHA022121-C017 Human pharmacology (Phase I) - Other Ended

Start 8 Aug 2024 · End 21 Oct 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol PHA022121-C017

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 14
Countries 1
Sites 1

Hereditary angioedema

Key facts

Sponsor
Pharvaris Netherlands B.V.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trial duration
8 Aug 2024 → 21 Oct 2024
Decision date (initial)
2024-07-29
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Hereditary angioedema

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Pharvaris Netherlands B.V.

Sponsor organisation
Pharvaris Netherlands B.V.
Address
J.H. Oortweg 21
City
Leiden
Postcode
2333 CH
Country
Netherlands

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ended 14 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ended
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2024-08-08 2024-10-21 2024-08-22 2024-09-18

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-17 Netherlands Acceptable
2024-07-29
2024-07-29