[14C]-BMS986504 Mass Balance Study in Patients with Advanced Solid Tumors with Homozygous MTAP Deletion

2024-515518-41-00 Protocol CA240-0008 Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 24 Mar 2025 · Status Ongoing, recruiting · 2 EU/EEA countries · 3 sites · Protocol CA240-0008

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 16
Countries 2
Sites 3

Advanced Solid Tumors

Key facts

Sponsor
Bristol-Myers Squibb Services Unlimited Company
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
24 Mar 2025 → ongoing
Decision date (initial)
2024-11-19
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-515518-41-00
WHO UTN
U1111-1308-9700

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced Solid Tumors

VersionLevelCodeTermSystem organ class
21.1 LLT 10065147 Malignant solid tumor 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bristol-Myers Squibb Services Unlimited Company

Sponsor organisation
Bristol-Myers Squibb Services Unlimited Company
Address
Plaza 254 Blanchardstown Corporate Park 2
City
Dublin 15
Postcode
D15 T867
Country
Ireland

Scientific contact point

Organisation
Bristol-Myers Squibb Services Unlimited Company
Contact name
GSM-CT

Public contact point

Organisation
Bristol-Myers Squibb Services Unlimited Company
Contact name
GSM-CT

Locations

2 EU/EEA countries · 3 investigational sites

By country

CountryMS statusPlanned subjectsSites
Hungary Ongoing, recruiting 8 1
Spain Ongoing, recruiting 8 2
Rest of world 0

Investigational sites

Hungary

1 site · Ongoing, recruiting
Pharmaceutical Research Associates Magyarorszag
PRA Klinikai Farmakológiai Vizsgálóhely, Rottenbiller Utca 13, 1077, Budapest

Spain

2 sites · Ongoing, recruiting
Hospital San Pedro
Centro de Invstigación Biom´+edicade La Rioja, Calle Piqueras 98, 26006, Logrono
Hospital Universitario Hm Sanchinarro
Centro Integral Oncológico Clara Campall, Calle Ona 10, 28050, Madrid

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Hungary 2025-03-24 2025-03-24
Spain 2026-03-06 2026-03-06

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-09-20 Hungary Acceptable
2024-11-18
2024-11-19
2 SUBSTANTIAL MODIFICATION SM-1 2025-03-05 Hungary Acceptable
2025-03-12
2025-03-13
3 SUBSTANTIAL MODIFICATION SM-2 2025-04-16 Hungary Acceptable
2025-06-03
2025-07-17
4 SUBSTANTIAL MODIFICATION SM-3 2025-07-29 Hungary Acceptable 2025-09-01
5 SUBSEQUENT ADDITION OF MSC APP-5 2025-10-23 Acceptable
2024-11-18
2026-02-02