Phase I study evaluating the safety and efficacy of MEDI5752 in combination with stereotactic radiotherapy in patients with metastatic sarcoma

2024-515551-38-00 Protocol 21 SARC 04 Human pharmacology (Phase I) - Other Ongoing, recruitment ended

Start 12 Dec 2023 · Status Ongoing, recruitment ended · 1 EU/EEA countries · 5 sites · Protocol 21 SARC 04

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruitment ended
Participants planned 20
Countries 1
Sites 5

Metastatic soft tissue sarcoma

Key facts

Sponsor
Oncopole Claudius Regaud
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
12 Dec 2023 → ongoing
Decision date (initial)
2024-08-09
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2024-515551-38-00
EudraCT number
2022-003754-31
ClinicalTrials.gov
NCT05821231

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Metastatic soft tissue sarcoma

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Oncopole Claudius Regaud

Sponsor organisation
Oncopole Claudius Regaud
Address
1 Avenue Irene Joliot Curie
City
Toulouse
Postcode
31100
Country
France

Scientific contact point

Organisation
Oncopole Claudius Regaud
Contact name
Dr Thibaud VALENTIN

Public contact point

Organisation
Oncopole Claudius Regaud
Contact name
Muriel MOUNIER

Locations

1 EU/EEA country · 5 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruitment ended 20 5
Rest of world 0

Investigational sites

France

5 sites · Ongoing, recruitment ended
Institut Regional Du Cancer De Montpellier
Medical oncology, 208 Avenue Des Apothicaires, 34298, Montpellier Cedex 5
Oncopole Claudius Regaud
Medical oncology, 1 Avenue Irene Joliot Curie, 31100, Toulouse
Centre Oscar Lambret
Medical oncology, 3 Rue Frederic Combemale, 59000, Lille
Centre Leon Berard
Medical oncology, 28 Rue Laennec, 69008, Lyon
Institut Bergonie
Medical oncology, 180 R De Saint Genes, 229 Cours De L Argonne, Bordeaux

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2023-12-12 2023-12-12 2025-06-17

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-07-17 France Acceptable
2024-08-09
2024-08-09
2 SUBSTANTIAL MODIFICATION SM-1 2024-10-11 France Acceptable
2025-01-13
2025-01-13
3 SUBSTANTIAL MODIFICATION SM-2 2025-09-26 France Acceptable
2025-10-07
2025-10-07