A randomized, Phase I, single-center, observer-blind, active-controlled study to evaluate the safety, tolerability and immunogenicity of one single administration of PCV-LITE, a novel adjuvanted pneumococcal conjugate vaccine at one dose level of LiteVax Adjuvant, in healthy participants aged 18-50 years.

2024-515972-11-00 Protocol PCV-LITE-I Human pharmacology (Phase I) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol PCV-LITE-I

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruitment pending
Participants planned 80
Countries 1
Sites 1

Pneumococcal infection

Key facts

Sponsor
LiteVax B.V.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Bacterial Infections and Mycoses [C01]
Decision date (initial)
2024-11-19
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Pneumococcal infection

VersionLevelCodeTermSystem organ class
21.1 LLT 10036897 Prophylactic vaccination 10042613

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

LiteVax B.V.

Sponsor organisation
LiteVax B.V.
Address
Akkersestraat 50
City
Ophemert
Postcode
4061 BJ
Country
Netherlands

Scientific contact point

Organisation
LiteVax B.V.
Contact name
Luuk Hilgers

Public contact point

Organisation
LiteVax B.V.
Contact name
Luuk Hilgers

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Authorised, recruitment pending 80 1
Rest of world 0

Investigational sites

Belgium

1 site · Authorised, recruitment pending
Universitair Ziekenhuis Gent
Center for Vaccinology (CEVAC), Corneel Heymanslaan 10, 9000, Gent

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-10-11 Belgium Acceptable
2024-11-19
2024-11-19